INT282365

Context Info Confidence 0.68 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 5 Disease Relevance 0.53 Pain Relevance 0.69

transport (Trpm5) plasma membrane (Trpm5) biological_process (Trpm5)

Anatomy Link Frequency taste receptor cells 2 Trpm5 (Mus musculus)

Pain Link Frequency Relevance Heat TRP channel 31 96.84 addiction 4 91.88 imagery 51 89.52 Action potential 1 80.76 c fibre 2 75.80 qutenza 28 71.96 Central nervous system 5 65.08 unmyelinated 2 61.08 adenocard 2 56.24 Peripheral nervous system 1 39.20

Disease Link Frequency Relevance Heat Targeted Disruption 52 99.96 Attention Deficit Hyperactivity Disorder 2 80.84 Overactive Bladder 2 80.28 Ganglion Cysts 40 5.00 Death 8 5.00 Loss Of Sense Of Smell 8 5.00 INFLAMMATION 4 5.00 Brain Injury 4 5.00 Body Weight 4 5.00 Apoptosis 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In taste receptor cells, stimulation of bitter, sweet and umami substances elevates intracellular Ca2+ levels, leading to activation of TRPM5 [44].

Positive_regulation (activation) of TRPM5 in taste receptor cells

1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.08 Pain Relevance 0.04

In taste receptor cells, TRPM5 is activated by the PLC pathway [47].

Positive_regulation (activated) of TRPM5 in taste receptor cells

2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0.09

Two independently generated TRPM5 knockout mouse models display diminished sweet, bitter, and umami perception.

Positive_regulation (generated) of TRPM5 associated with targeted disruption

3) Confidence 0.48 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.22 Pain Relevance 0.14

TRPM5 is also temperature-sensitive, being activated by heat in the range of 15–35°C.

Positive_regulation (activated) of TRPM5

4) Confidence 0.45 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.23 Pain Relevance 0.20

In contrast to the four heat- or cold-sensitive TRPV1, TRPV2, TRPM8, and TRPA1, two TRPV (TRPV3 and TRPV4) and three TRPM (TRPM2, TRPM4, and TRPM5) channels have been found to be activated by warm stimuli [10, 13, 38, 39].

Positive_regulation (activated) of TRPM5

5) Confidence 0.34 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0 Pain Relevance 0.22

General Comments

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