INT282365

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Context Info
Confidence 0.68
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 0.53
Pain Relevance 0.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpm5) plasma membrane (Trpm5) biological_process (Trpm5)
Anatomy Link Frequency
taste receptor cells 2
Trpm5 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 31 96.84 Very High Very High Very High
addiction 4 91.88 High High
imagery 51 89.52 High High
Action potential 1 80.76 Quite High
c fibre 2 75.80 Quite High
qutenza 28 71.96 Quite High
Central nervous system 5 65.08 Quite High
unmyelinated 2 61.08 Quite High
adenocard 2 56.24 Quite High
Peripheral nervous system 1 39.20 Quite Low
Disease Link Frequency Relevance Heat
Targeted Disruption 52 99.96 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 2 80.84 Quite High
Overactive Bladder 2 80.28 Quite High
Ganglion Cysts 40 5.00 Very Low Very Low Very Low
Death 8 5.00 Very Low Very Low Very Low
Loss Of Sense Of Smell 8 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low
Brain Injury 4 5.00 Very Low Very Low Very Low
Body Weight 4 5.00 Very Low Very Low Very Low
Apoptosis 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In taste receptor cells, stimulation of bitter, sweet and umami substances elevates intracellular Ca2+ levels, leading to activation of TRPM5 [44].
Positive_regulation (activation) of TRPM5 in taste receptor cells
1) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0.08 Pain Relevance 0.04
In taste receptor cells, TRPM5 is activated by the PLC pathway [47].
Positive_regulation (activated) of TRPM5 in taste receptor cells
2) Confidence 0.49 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912856 Disease Relevance 0 Pain Relevance 0.09
Two independently generated TRPM5 knockout mouse models display diminished sweet, bitter, and umami perception.
Positive_regulation (generated) of TRPM5 associated with targeted disruption
3) Confidence 0.48 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.22 Pain Relevance 0.14
TRPM5 is also temperature-sensitive, being activated by heat in the range of 15–35°C.
Positive_regulation (activated) of TRPM5
4) Confidence 0.45 Published 2010 Journal Acta Oto-Laryngologica Section Body Doc Link PMC2981077 Disease Relevance 0.23 Pain Relevance 0.20
In contrast to the four heat- or cold-sensitive TRPV1, TRPV2, TRPM8, and TRPA1, two TRPV (TRPV3 and TRPV4) and three TRPM (TRPM2, TRPM4, and TRPM5) channels have been found to be activated by warm stimuli [10, 13, 38, 39].
Positive_regulation (activated) of TRPM5
5) Confidence 0.34 Published 2009 Journal Pflugers Arch Section Body Doc Link PMC2745623 Disease Relevance 0 Pain Relevance 0.22

General Comments

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