INT2824

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Context Info
Confidence 0.40
First Reported 1979
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 10.41
Pain Relevance 1.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (HTN1)
Anatomy Link Frequency
blood 1
plasma 1
capillary 1
brain 1
14.2 1
HTN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Trigeminal neuralgia 10 99.40 Very High Very High Very High
Arthritis 2 99.04 Very High Very High Very High
depression 2 98.48 Very High Very High Very High
diclofenac 3 94.80 High High
headache 9 86.64 High High
Pain 1 86.28 High High
cINOD 10 75.00 Quite High
cva 64 53.96 Quite High
Angina 4 36.00 Quite Low
beta blocker 21 34.72 Quite Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 172 100.00 Very High Very High Very High
Hypertension 164 100.00 Very High Very High Very High
Syndrome 5 100.00 Very High Very High Very High
Myocardial Infarction 44 99.64 Very High Very High Very High
Colon Cancer 124 99.62 Very High Very High Very High
Facial Pain 11 99.40 Very High Very High Very High
Arthritis 2 99.04 Very High Very High Very High
Depression 2 98.48 Very High Very High Very High
Proteinuria 29 98.30 Very High Very High Very High
Heart Disease 2 98.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A total of 84 patients (54 females; 30 males) between the ages of 33 and 93 years were diagnosed with TN; 37% had TN with HTN and 32% of controls had HTN.
Positive_regulation (had) of HTN associated with hypertension and trigeminal neuralgia
1) Confidence 0.40 Published 2009 Journal J Headache Pain Section Abstract Doc Link 19277836 Disease Relevance 1.77 Pain Relevance 0.97
An IQR increase in 4-hr NO2 concentrations (10.75 ppb) was associated with a 6.9% (95% CI, 0.1–14.2) increase in SDNN in individuals with COPD and a 13.9% (95% CI, –22.2 to –4.7) decrease in SDNN in persons with a recent MI.
Positive_regulation (increase) of ppb in 14.2 associated with pulmonary disease and myocardial infarction
2) Confidence 0.12 Published 2006 Journal Environ Health Perspect Section Body Doc Link PMC1440781 Disease Relevance 0.89 Pain Relevance 0
Despite the effort to increase the awareness and treatment of HTN, recent data for the US show that only 39% of patients have their BP adequately controlled.5 In Europe, BP control was achieved in only 12% of Polish hypertensives and up to 36% of Spanish hypertensives.6 These statistics show the need to change the landscape of BP management.


Positive_regulation (increase) of HTN associated with pressure and volume under development
3) Confidence 0.09 Published 2010 Journal Core evidence Section Body Doc Link PMC2899780 Disease Relevance 1.27 Pain Relevance 0.10
In HTN without any other associated cardiovascular risk factor, the treatment cost increases as the target for HTN is lowered but this effect is attenuated when the population tested is older or has higher cardiovascular risk.
Positive_regulation (increases) of HTN associated with pressure and volume under development
4) Confidence 0.06 Published 2010 Journal Core evidence Section Body Doc Link PMC2899780 Disease Relevance 1.19 Pain Relevance 0.09
In 10 subjects who took indomethacin 150 mg/d p.o. for 3 days, plasma post-heparin lipoprotein lipase activity was also significantly increased.
Positive_regulation (increased) of post-heparin in plasma
5) Confidence 0.04 Published 1981 Journal Eur. J. Clin. Pharmacol. Section Abstract Doc Link 6796423 Disease Relevance 0.07 Pain Relevance 0.21
Other mechanisms involving the renin-angiotensin system, endothelial dysfunction and capillary rarefaction have also been proposed.83,84 There was initial suggestion of a correlation between the dose of bevacizumab and development of HTN and proteinuria.85 A phase II study with bevacizumab dosed at 10 mg/kg was associated with a higher incidence of all grade HTN (28% versus 11%) compared with the standard dose of bevacizumab (5 mg/kg).86 However, subsequent phase III studies which used 10 mg/kg of bevacizumab showed the incidence of HTN to be much lower (grade 3 HTN 5.2%).56
Positive_regulation (incidence) of HTN in capillary associated with pressure and volume under development and proteinuria
6) Confidence 0.02 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886334 Disease Relevance 1.61 Pain Relevance 0
Initial phase II trials in metastatic CRC revealed a higher incidence of HTN in patients treated with bevacizumab (grade 3 16%).81 Subsequently, the pivotal phase III trial of IFL with or without bevacizumab in metastatic CRC showed similar results (all grade HTN: 22.4%; grade 3 HTN: 11%, and grade 4 HTN: 0%–1%).9 The mechanism of bevacizumab-related HTN is unclear and has been attributed to possible alterations in the nitric oxide signaling pathway.82 VEGF inhibition by bevacizumab results in vasoconstriction of blood vessels with a resulting increase in blood pressure.
Positive_regulation (incidence) of HTN in blood associated with pressure and volume under development, colon cancer and increased venous pressure under development
7) Confidence 0.02 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886334 Disease Relevance 1.72 Pain Relevance 0
The older hypertensive population with its higher incidence of multiple comorbidities requires an aggressive approach to choice of therapeutic regimen(s), intensity of therapy, consideration of the increased incidence of resistant HTN and ultimately, the goals of care (ie, which treatment guidelines will take precedence in a given patient’s circumstances).
Positive_regulation (increased) of HTN associated with hypertension
8) Confidence 0.01 Published 2010 Journal Vascular Health and Risk Management Section Body Doc Link PMC2922317 Disease Relevance 1.37 Pain Relevance 0.03
In order to evaluate the present incidence of post-pericardiotomy syndrome (PPS) and the reliability of conventional diagnostic methods in its detection, 194 consecutive patients were studied by echocardiography one month after cardiac surgery and thereafter every third month up to one year, and also during hospitalization if symptoms or signs of PPS appeared.
Positive_regulation (incidence) of post-pericardiotomy syndrome associated with syndrome
9) Confidence 0.00 Published 1979 Journal Scand J Thorac Cardiovasc Surg Section Abstract Doc Link 542834 Disease Relevance 0.51 Pain Relevance 0
Figure 4 shows an example of histological appearance of brain sections from an animal where BBB disruption was not induced; this was also previously quantified by contrast-enhanced MRI and post-mortem histological evaluation of Evan Blue (Figure 2).
Positive_regulation (enhanced) of post-mortem in brain
10) Confidence 0.00 Published 2010 Journal BMC Neurosci Section Body Doc Link PMC2842276 Disease Relevance 0 Pain Relevance 0

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