INT282434

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 2.85
Pain Relevance 1.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Psen1) Golgi apparatus (Psen1) endoplasmic reticulum (Psen1)
intracellular (Psen1) embryo development (Psen1) protein complex (Psen1)
Psen1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 40 97.32 Very High Very High Very High
cINOD 44 96.92 Very High Very High Very High
adenocard 6 90.60 High High
Inflammation 43 84.88 Quite High
Neurotransmitter 3 75.60 Quite High
agonist 2 75.04 Quite High
diclofenac 1 61.20 Quite High
addiction 4 10.00 Low Low
Inflammatory response 14 5.00 Very Low Very Low Very Low
Hippocampus 12 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Neuroblastoma 6 99.76 Very High Very High Very High
Disease 235 95.04 Very High Very High Very High
INFLAMMATION 64 84.88 Quite High
Alzheimer's Dementia 59 73.92 Quite High
Cognitive Disorder 34 69.68 Quite High
Targeted Disruption 31 69.04 Quite High
Aging 63 65.64 Quite High
Increased Venous Pressure Under Development 7 59.96 Quite High
Hyperhomocysteinemia 15 51.84 Quite High
Vascular Dementia 1 35.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, AdoMet administration in human neuroblastoma cells down regulates PS1 gene expression and A?
Regulation (regulates) of Gene_expression (expression) of PS1 gene associated with neuroblastoma
1) Confidence 0.50 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.57 Pain Relevance 0.12
production through the regulation of Presenilin1 (PS1) expression.
Regulation (regulation) of Gene_expression (expression) of PS1
2) Confidence 0.50 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.62 Pain Relevance 0.12
and by regulating the presenilin/?
Regulation (regulating) of Gene_expression (/) of presenilin
3) Confidence 0.38 Published 2010 Journal Frontiers in Aging Neuroscience Section Body Doc Link PMC2887037 Disease Relevance 0.71 Pain Relevance 1.04
production through the regulation of Presenilin1 (PS1) expression.
Regulation (regulation) of Gene_expression (expression) of Presenilin1
4) Confidence 0.37 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.62 Pain Relevance 0.12
-secretase complexes, and such PS1 conformation may be responsible for a shift towards the A?
Regulation (responsible) of Gene_expression (conformation) of PS1
5) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.05 Pain Relevance 0.07
We propose a hypothesis of “structure-function correlation” implying that structural changes in the PS1/?
Regulation (changes) of Gene_expression (/) of PS1
6) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0.27 Pain Relevance 0
We employ a molecular imaging methodology, such as FRET-based microscopy, to show that this probe allows monitoring, and accurately reflects consistent structural changes of the PS1 molecule in live cells, and that these changes closely correlate with changes in the A?
Regulation (changes) of Gene_expression (molecule) of PS1 associated with imagery
7) Confidence 0.33 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0.05
This indicates that elongation of the Pen-2 N-terminus correlates with the change in PS1 conformation, which in turn leads to an increase in A?
Regulation (change) of Gene_expression (conformation) of PS1
8) Confidence 0.29 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2773935 Disease Relevance 0 Pain Relevance 0
On the other hand, both pS1 and pS2 sequences bear the C residue in the neighborhood of the ?
Regulation (bear) of Gene_expression (sequences) of pS1
9) Confidence 0.05 Published 2010 Journal Mol Genet Genomics Section Body Doc Link PMC2939334 Disease Relevance 0 Pain Relevance 0

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