INT282439

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Context Info
Confidence 0.47
First Reported 2009
Last Reported 2009
Negated 4
Speculated 2
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 4.66
Pain Relevance 0.11

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
brain 3
Mat1a (Mus musculus)
Pain Link Frequency Relevance Heat
Hippocampus 16 94.24 High High
adenocard 16 35.24 Quite Low
Spinal cord 8 25.00 Low Low
Neurotransmitter 8 20.24 Low Low
anesthesia 8 16.92 Low Low
Disease Link Frequency Relevance Heat
Disease 304 98.84 Very High Very High Very High
Death 8 98.08 Very High Very High Very High
Cognitive Disorder 56 97.48 Very High Very High Very High
Aging 152 95.80 Very High Very High Very High
Urological Neuroanatomy 8 95.00 High High
Frailty 8 91.88 High High
Targeted Disruption 24 80.16 Quite High
Stress 8 67.12 Quite High
Neuroblastoma 16 61.84 Quite High
Hyperhomocysteinemia 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition, it is still unknown whether alterations in AdoMet and AdoHcy levels are cause or consequence of AD pathology.
Spec (whether) Regulation (alterations) of AdoMet associated with disease
1) Confidence 0.47 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.87 Pain Relevance 0.03
In addition, we showed that cholesterol-containing, or DHA-enriched diets did not affect AdoMet or AdoHcy levels in brain tissue of APP/PS1 and wild-type mice.
Neg (not) Regulation (affect) of AdoMet in brain
2) Confidence 0.47 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.59 Pain Relevance 0
If the above-mentioned hypothesis is valid, and AdoMet remains unaltered in aged APP/PS1 mice compared to young APP/PS1 mice, because of less demand for methylation due to neurodegeneration, AdoHcy levels will also be expected to be decreased or unchanged.
Regulation (unaltered) of AdoMet
3) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.61 Pain Relevance 0.05
The finding that cholesterol- or DHA-containing diets do not alter AdoMet or AdoHcy levels in brain tissue of either wild type or APP/PS1 mice, but in contrast do have effects on AD pathology and cerebral hemodynamics [7, 15, 29], suggests that cholesterol- or DHA-containing diets do not influence cerebral hemodynamics or AD pathology via the methylation cycle.
Neg (not) Regulation (alter) of AdoMet in brain associated with disease
4) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.59 Pain Relevance 0
Neither a cholesterol- nor a DHA-containing diet did alter AdoMet or AdoHcy levels in brain tissue of 8- and 15-month-old APP/PS1 and wild-type mice as compared to the standard diet (data not shown).


Neg (Neither) Regulation (alter) of AdoMet in brain
5) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.63 Pain Relevance 0
The finding that AdoMet levels significantly differ only in 15-month-old APP/PS1 mice compared to their wild-type littermates, but not in 8-month-old mice, also indicates that alterations in AdoMet levels are a consequence of AD pathology rather than a cause.
Regulation (alterations) of AdoMet associated with disease
6) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.56 Pain Relevance 0
No changes in AdoMet and AdoHcy levels, and consequently in the ratio between AdoMet and AdoHcy levels (methylation index), were observed between 8-month-old wild type and APP/PS1 mice (Fig. 1a–c).
Neg (No) Regulation (changes) of AdoMet
7) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.09 Pain Relevance 0
AdoMet and AdoHcy might also influence AD like pathology and vascular health [16] and it could be hypothesized that the above-mentioned nutritional components may influence and AdoMet and AdoHcy levels as well.


Spec (may) Regulation (influence) of AdoMet associated with disease
8) Confidence 0.20 Published 2009 Journal Neurol Sci Section Body Doc Link PMC2746292 Disease Relevance 0.73 Pain Relevance 0.04

General Comments

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