INT28247

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Context Info
Confidence 0.14
First Reported 1989
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.84
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (CD8A) plasma membrane (CD8A)
Anatomy Link Frequency
lymphocytes 2
T-lymphocyte 2
CD8A (Homo sapiens)
Pain Link Frequency Relevance Heat
anesthesia 4 82.32 Quite High
spinal stenosis 5 65.28 Quite High
cytokine 91 53.52 Quite High
Inflammation 96 46.92 Quite Low
chemokine 23 25.84 Quite Low
antagonist 34 5.00 Very Low Very Low Very Low
agonist 20 5.00 Very Low Very Low Very Low
Inflammatory response 6 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Asthma 315 99.04 Very High Very High Very High
Infection 24 97.28 Very High Very High Very High
Disease 22 90.44 High High
Bacterial Infection 3 89.20 High High
Wound Infection 5 86.40 High High
Pneumonia 13 85.04 High High
Malignant Neoplastic Disease 2 84.32 Quite High
Urinary Tract Infection 6 84.16 Quite High
Virus Diseases 2 77.80 Quite High
Staphylococcus Infection 3 77.04 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Increased postoperative infection during homologous transfusion was correlated with a higher level of plasma immunosuppressive factor,38 drop in natural killer cells,36 decrease in the number of auxiliary CD4 lymphocytes,39 increase in the number of CD8 suppressor lymphocytes, 39 and suppressed cell-mediated immunity.40
Negative_regulation (decrease) of Positive_regulation (increase) of CD8 in lymphocytes associated with infection
1) Confidence 0.14 Published 2006 Journal Yonsei Medical Journal Section Body Doc Link PMC2687825 Disease Relevance 1.81 Pain Relevance 0.06
In addition, there is correlation between the down regulation of CD4 and CD8 T-lymphocyte activation and the improvement in asthma control.
Negative_regulation (regulation) of Positive_regulation (activation) of T-lymphocyte in T-lymphocyte associated with asthma
2) Confidence 0.11 Published 2008 Journal J Occup Med Toxicol Section Body Doc Link PMC2259400 Disease Relevance 0.62 Pain Relevance 0.03
Decrease in OKT4, OKT4/OKT8 ratio, Leu12 and HLA-Dr, and increase in OKT8 were observed during the operation.
Negative_regulation (Decrease) of Positive_regulation (increase) of OKT8
3) Confidence 0.01 Published 1989 Journal Masui Section Abstract Doc Link 2739066 Disease Relevance 0.41 Pain Relevance 0.16

General Comments

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