INT282473

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Context Info
Confidence 0.71
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 5
Disease Relevance 3.11
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlgap3) protein complex assembly (Dlgap3) cell-cell signaling (Dlgap3)
Anatomy Link Frequency
synapses 2
striatum 1
nervous system 1
Dlgap3 (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 170 91.04 High High
Catechol-O-methyltransferase 35 62.76 Quite High
Glutamate 85 61.20 Quite High
fluoxetine 10 57.76 Quite High
Dopamine 25 31.20 Quite Low
nMDA receptor 65 5.00 Very Low Very Low Very Low
Serotonin 55 5.00 Very Low Very Low Very Low
Neurotransmitter 35 5.00 Very Low Very Low Very Low
behavioral therapy 35 5.00 Very Low Very Low Very Low
amygdala 30 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 1045 99.80 Very High Very High Very High
Autism 5 94.28 High High
Congenital Anomalies 35 83.12 Quite High
Alopecia 5 77.28 Quite High
Urological Neuroanatomy 5 35.48 Quite Low
Targeted Disruption 25 6.72 Low Low
Obsessive-compulsive Disorder 60 5.00 Very Low Very Low Very Low
Cognitive Disorder 45 5.00 Very Low Very Low Very Low
Tourette's Syndrome 45 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 45 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SAP90/PSD95-associated protein 3 (SAPAP3) belongs to a family of four homologous genes encoding SAPAP proteins that are widely yet differentially expressed in the nervous system [95].
Gene_expression (expressed) of SAPAP3 in nervous system
1) Confidence 0.71 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.46 Pain Relevance 0.10
SAP90/PSD95-associated protein 3 (SAPAP3) is a postsynaptic scaffolding protein at excitatory synapses that is highly expressed in the striatum [95].
Gene_expression (expressed) of SAPAP3 in striatum
2) Confidence 0.71 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.67 Pain Relevance 0
SAPAP3 is the only family member that is strongly expressed in the striatum [95], thus offering a unique opportunity to explore the specific function of SAPAP3 at glutamatergic synapses in this brain region.
Gene_expression (expressed) of SAPAP3 in synapses
3) Confidence 0.71 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.57 Pain Relevance 0.03
No clear association between SAPAP3 variants and OCD was reported, although it is noteworthy that GDs without OCD were uncommon in this study.
Gene_expression (variants) of SAPAP3 associated with anxiety disorder
4) Confidence 0.62 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.83 Pain Relevance 0.03
Consistent with the predicted function of the SAPAP3 protein, SAPAP3 null mice were also found to have defects in glutamatergic transmission at cortico-striatal synapses (a feature that is only known to be shared by the DAT KD mice thus far, but has been suggested as a central defect for D1CT mice), and remarkably, both synaptic and behavioral defects were rescued by virus-mediated reintroduction of SAPAP3 specifically into the striatum [96].
Gene_expression (reintroduction) of SAPAP3 in synapses
5) Confidence 0.62 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.58 Pain Relevance 0.06

General Comments

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