INT282479

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Context Info
Confidence 0.45
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 1.17
Pain Relevance 0.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Comt) methyltransferase activity (Comt) plasma membrane (Comt)
Comt (Mus musculus)
Pain Link Frequency Relevance Heat
Catechol-O-methyltransferase 61 100.00 Very High Very High Very High
Dopamine 35 100.00 Very High Very High Very High
sSRI 34 67.32 Quite High
cocaine 1 52.88 Quite High
Hippocampus 19 25.00 Low Low
addiction 6 20.80 Low Low
Neurotransmitter 17 5.00 Very Low Very Low Very Low
Glutamate 17 5.00 Very Low Very Low Very Low
nMDA receptor 13 5.00 Very Low Very Low Very Low
Nucleus accumbens 13 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cognitive Disorder 21 95.36 Very High Very High Very High
Urological Neuroanatomy 1 93.52 High High
Aggression 6 91.76 High High
Anxiety Disorder 211 90.80 High High
Targeted Disruption 5 77.20 Quite High
Sprains And Strains 114 64.88 Quite High
Congenital Anomalies 7 61.56 Quite High
Tourette's Syndrome 9 22.36 Low Low
Attention Deficit Hyperactivity Disorder 9 21.84 Low Low
Drug Dependence 3 20.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine.
Regulation (responsible) of Protein_catabolism (degradation) of COMT associated with catechol-o-methyltransferase and dopamine
1) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923157 Disease Relevance 0.25 Pain Relevance 0.20
Catechol-O-methyltransferase (COMT) is a key enzyme responsible for the degradation of dopamine and norepinephrine.
Regulation (responsible) of Protein_catabolism (degradation) of Catechol-O-methyltransferase associated with catechol-o-methyltransferase and dopamine
2) Confidence 0.45 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2923157 Disease Relevance 0.25 Pain Relevance 0.20
This disruption is likely to influence dopamine signaling since COMT is a major enzyme regulating dopamine degradation [115].
Regulation (regulating) of Protein_catabolism (degradation) of COMT associated with catechol-o-methyltransferase and dopamine
3) Confidence 0.33 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.67 Pain Relevance 0.45

General Comments

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