INT282484

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Context Info
Confidence 0.74
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.66
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Dlgap3) protein complex assembly (Dlgap3) cell-cell signaling (Dlgap3)
Anatomy Link Frequency
striatum 1
Dlgap3 (Mus musculus)
Pain Link Frequency Relevance Heat
fluoxetine 2 74.72 Quite High
sSRI 34 26.24 Quite Low
Glutamate 17 5.00 Very Low Very Low Very Low
nMDA receptor 13 5.00 Very Low Very Low Very Low
Serotonin 11 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 7 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
behavioral therapy 7 5.00 Very Low Very Low Very Low
amygdala 6 5.00 Very Low Very Low Very Low
deep brain stimulation 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 209 94.00 High High
Alopecia 1 68.72 Quite High
Congenital Anomalies 7 64.96 Quite High
Obsessive-compulsive Disorder 12 5.00 Very Low Very Low Very Low
Cognitive Disorder 9 5.00 Very Low Very Low Very Low
Tourette's Syndrome 9 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 9 5.00 Very Low Very Low Very Low
Chorea 5 5.00 Very Low Very Low Very Low
Streptococcal Infections 5 5.00 Very Low Very Low Very Low
Targeted Disruption 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Given the high expression and postsynaptic localization of SAPAP3 at glutamatergic synapses in the striatum, these findings fit well within the existing framework of glutamatergic dysfunction in the CSTC circuit in OCD.
Localization (localization) of SAPAP3 in striatum associated with anxiety disorder
1) Confidence 0.74 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.66 Pain Relevance 0.07

General Comments

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