INT282485

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Context Info
Confidence 0.17
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.94
Pain Relevance 0.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gpbar1) plasma membrane (Gpbar1) signal transducer activity (Gpbar1)
Anatomy Link Frequency
central nervous system 2
Gpbar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 1 99.04 Very High Very High Very High
Serotonin 11 99.00 Very High Very High Very High
sSRI 34 95.08 Very High Very High Very High
Hippocampus 1 49.76 Quite Low
Clonidine 2 31.92 Quite Low
Glutamate 17 5.00 Very Low Very Low Very Low
nMDA receptor 13 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 7 5.00 Very Low Very Low Very Low
Neurotransmitter 7 5.00 Very Low Very Low Very Low
behavioral therapy 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 209 94.36 High High
Aggression 2 90.00 High High
Obesity 2 78.32 Quite High
Death 1 75.20 Quite High
Convulsion 2 73.76 Quite High
Skin Abnormalities 1 64.80 Quite High
Congenital Anomalies 7 46.56 Quite Low
Tourette's Syndrome 9 30.88 Quite Low
Targeted Disruption 5 5.44 Low Low
Obsessive-compulsive Disorder 12 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The 5-HT2C subtype of the serotonin receptor family is a G-protein coupled receptor (GPCR) that is broadly expressed in the brain and is proposed to mediate many of the central nervous system actions of serotonin, including those underlying the therapeutic benefit of SSRI treatment in OCD [15].
Positive_regulation (proposed) of Gene_expression (expressed) of GPCR in central nervous system associated with anxiety disorder, central nervous system, ssri and serotonin
1) Confidence 0.17 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.94 Pain Relevance 0.24

General Comments

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