INT282488

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.38
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neural 1
ocd (Mus musculus)
Pain Link Frequency Relevance Heat
sSRI 102 99.34 Very High Very High Very High
Serotonin 33 96.32 Very High Very High Very High
Central nervous system 3 84.88 Quite High
Hippocampus 3 74.96 Quite High
Clonidine 6 57.12 Quite High
Glutamate 51 8.88 Low Low
nMDA receptor 39 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 21 5.00 Very Low Very Low Very Low
Neurotransmitter 21 5.00 Very Low Very Low Very Low
behavioral therapy 21 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 627 100.00 Very High Very High Very High
Aggression 6 96.04 Very High Very High Very High
Skin Abnormalities 3 90.00 High High
Obesity 6 65.12 Quite High
Death 3 62.00 Quite High
Convulsion 6 60.56 Quite High
Autism 3 58.08 Quite High
Tourette's Syndrome 27 56.08 Quite High
Congenital Anomalies 21 33.36 Quite Low
Obsessive-compulsive Disorder 36 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The extensive expression of Hoxb8 in virtually all regions of the CSTC circuit that is disrupted in OCD indicates strong potential for the involvement of Hoxb8 gene disruption in forms of human OCD and/or TTM.
Negative_regulation (disrupted) of OCD associated with anxiety disorder
1) Confidence 0.43 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.81 Pain Relevance 0.24
The combined load of these rare SAPAP3 mutations was 4.2% of the OCD/TTM case samples compared to only 1.1% in control samples, providing tentative support for a role of SAPAP3 in OCD and TTM.
Negative_regulation (role) of OCD associated with anxiety disorder
2) Confidence 0.36 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.70 Pain Relevance 0
The Hoxb8 mutant mice have not been tested for response to SSRIs, and the neural basis for their OCD-like behaviors remains entirely unexplored.

5-HT2C Null Mice

Negative_regulation (unexplored) of OCD in neural associated with anxiety disorder and ssri
3) Confidence 0.32 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.86 Pain Relevance 0.25

General Comments

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