INT28249

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Context Info
Confidence 0.70
First Reported 1983
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 25
Total Number 28
Disease Relevance 13.63
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (HLA-DRA) Golgi apparatus (HLA-DRA) endoplasmic reticulum (HLA-DRA)
plasma membrane (HLA-DRA) lysosome (HLA-DRA)
Anatomy Link Frequency
CD86 5
T cells 5
monocytes 2
mononuclear cells 2
blood 1
HLA-DRA (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 28 100.00 Very High Very High Very High
Pain 18 100.00 Very High Very High Very High
pain flank 1 97.40 Very High Very High Very High
carbamazepine 6 96.72 Very High Very High Very High
anticonvulsant 3 95.52 Very High Very High Very High
cytokine 196 95.20 Very High Very High Very High
Inflammation 239 93.72 High High
Leflunomide 54 92.48 High High
cINOD 13 90.64 High High
anesthesia 41 85.28 High High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 29 100.00 Very High Very High Very High
Pain 20 100.00 Very High Very High Very High
Disease 110 99.34 Very High Very High Very High
Cancer 214 99.28 Very High Very High Very High
Hypersensitivity 35 98.76 Very High Very High Very High
Solid Tumor 8 98.64 Very High Very High Very High
Phototoxic Dermatitis 36 97.88 Very High Very High Very High
Flank Pain 1 97.40 Very High Very High Very High
Skin Cancer 5 97.36 Very High Very High Very High
Colon Cancer 9 97.32 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Fractionation of human peripheral blood over Hypaque-Ficoll and subsequent purification of monocytes by adherence to plastic lead to an increase in the relative density of HLA-DR on monocytes.
Positive_regulation (increase) of HLA-DR in monocytes
1) Confidence 0.70 Published 1989 Journal J. Surg. Res. Section Abstract Doc Link 2739399 Disease Relevance 0.08 Pain Relevance 0.13
Human urinary beta 2-microglobulin (beta 2m) and pa-pain-solubilized human histocompatibility antigen HLA-B7 were iodinated with iodogen and the sites of iodination determined.
Positive_regulation (pa-pain-solubilized) of histocompatibility antigen HLA-B7 associated with pain
2) Confidence 0.36 Published 1983 Journal Biochemistry Section Abstract Doc Link 6188486 Disease Relevance 0.10 Pain Relevance 0.10
Interestingly, photohaptenic properties were also described by Hino et al. [34] where SPFX treatment of THP-1 cells only resulted in enhanced HLA-DR but not CD86 or CD54 expression.
Positive_regulation (resulted) of HLA-DR in CD86
3) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.31 Pain Relevance 0.09
Interestingly, photohaptenic properties were also described by Hino et al. [34] where SPFX treatment of THP-1 cells only resulted in enhanced HLA-DR but not CD86 or CD54 expression.
Neg (not) Positive_regulation (enhanced) of HLA-DR in CD86
4) Confidence 0.26 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.31 Pain Relevance 0.09
In addition, hydrocortisone, and to a lesser extent IL-10, reversed the up-regulation of HLA-DR induced by bacterial products.
Positive_regulation (induced) of HLA-DR
5) Confidence 0.26 Published 2010 Journal Crit Care Section Abstract Doc Link PMC2887183 Disease Relevance 0.05 Pain Relevance 0
As compared to IL-10, hydrocortisone had a greater capacity to reduce the up-regulation of HLA-DR induced by PAMPs, especially on CD14HIGH monocytes.
Positive_regulation (induced) of HLA-DR in monocytes
6) Confidence 0.26 Published 2010 Journal Crit Care Section Body Doc Link PMC2887183 Disease Relevance 0 Pain Relevance 0.16
These data indicate that transition of parabasal into intermediate epithelial cells at the pb/im interface is associated with transformation of DC precursors into mature DC with the assistance of activated (HLA-DR) T cells.
Positive_regulation (activated) of HLA-DR in T cells
7) Confidence 0.15 Published 2001 Journal BMC Dev Biol Section Body Doc Link PMC34117 Disease Relevance 0.27 Pain Relevance 0
in both WJMSCs [50] and BMMSCs [46] HLA-DR was only mildly induced in WJMSCs as compared to BMMSCs in our hands.
Positive_regulation (induced) of HLA-DR
8) Confidence 0.14 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.30 Pain Relevance 0.19
Dose-dependent increases in CD86 and HLA-DR (but not CD83) expression were observed at radiation doses >1 J/cm2 UVA.
Positive_regulation (increases) of HLA-DR in CD86
9) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3009729 Disease Relevance 0.28 Pain Relevance 0
Although HLA-DR has been reported to be greatly induced by IFN?
Positive_regulation (reported) of HLA-DR
10) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.28 Pain Relevance 0.18
HLA-DR was induced only in BMMSCs on IFN?
Positive_regulation (induced) of HLA-DR
11) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2814860 Disease Relevance 0.22 Pain Relevance 0.15
Blast cells were positive for CD7, CD13, CD33, CD34, and HLA-DR, and negative for CD56.
Positive_regulation (positive) of HLA-DR in Blast cells
12) Confidence 0.09 Published 2001 Journal Rinsho Ketsueki Section Abstract Doc Link 11579505 Disease Relevance 1.00 Pain Relevance 0.08
They were positive for CD 5, 19, 20, 22, 23, HLA-DR, IgM, IgD and kappa chain.
Positive_regulation (positive) of HLA-DR
13) Confidence 0.07 Published 2002 Journal Rinsho Ketsueki Section Abstract Doc Link 12229129 Disease Relevance 0.74 Pain Relevance 0.06
In contrast, the percentage of CD4+ T cells co-expressing the activation marker HLA-DR was significantly higher in infected than in uninfected animals (p?
Positive_regulation (activation) of HLA-DR in T cells
14) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2698465 Disease Relevance 0.24 Pain Relevance 0
Circulating blasts were positive for CD4, CD7, CD25, CD13, CD33, CD34, and HLA-DR and partly positive for CD41 and CD36.
Positive_regulation (positive) of HLA-DR
15) Confidence 0.06 Published 1995 Journal Rinsho Ketsueki Section Abstract Doc Link 8531333 Disease Relevance 0.51 Pain Relevance 0.08
Further, it was shown that 5-aza-2'-deoxycytidine leads to re-expression of HLA class I antigens and restoration of antigen-specific CTL response in melanoma cells [48]; likewise, it has been shown that methylation-induced silencing of the class II transactivator (CIITA) leads to lack of HLA-DR induction in hematopoietic tumor cells and solid tumors such as gastric and colorectal carcinomas [49,50].


Positive_regulation (induction) of HLA-DR associated with cancer, colon cancer, solid tumor and skin cancer
16) Confidence 0.05 Published 2006 Journal J Transl Med Section Body Doc Link PMC1413557 Disease Relevance 0.86 Pain Relevance 0
Immunohistochemistry is variable, but in most cases, staining is positive for CD68, CD4, CD45, HLA-DR, and lysozyme, but negative for S100, CD20, and factor XIIIa [7].
Positive_regulation (positive) of HLA-DR
17) Confidence 0.05 Published 2009 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC2770547 Disease Relevance 1.06 Pain Relevance 0.10
With regard to peripheral blood mononuclear cells (PBMCs), a randomized study of human colectomy patients demonstrated a small but significant difference in expression of the human leukocyte antigen marker (HLA-DR) on circulating monocytes in favor of the laparoscopic patients on the POD 4 [27].
Positive_regulation (difference) of HLA-DR in mononuclear cells
18) Confidence 0.04 Published 2009 Journal Surg Endosc Section Body Doc Link PMC2814196 Disease Relevance 0.32 Pain Relevance 0.03
In the degenerating subcutaneous fatty tissue, positive staining for HLA-DR, Fas, bcl-2, p53 and transferase-mediated uridine nick end labeling in mononuclear cells were observed.
Positive_regulation (staining) of HLA-DR in mononuclear cells
19) Confidence 0.04 Published 2000 Journal Dermatology (Basel) Section Abstract Doc Link 11146355 Disease Relevance 0.73 Pain Relevance 0.17
Of note, induction of mRNAs for CD40, CD86, and HLA-DR in ??
Positive_regulation (induction) of HLA-DR in CD86
20) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0 Pain Relevance 0

General Comments

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