INT282505

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Context Info
Confidence 0.39
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 4.22
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
synapses 2
ocd (Mus musculus)
Slc1a1 (Mus musculus)
Pain Link Frequency Relevance Heat
Glutamate 119 100.00 Very High Very High Very High
excitatory amino acid 7 95.84 Very High Very High Very High
nMDA receptor 91 79.76 Quite High
Glutamate receptor 28 61.48 Quite High
Neurotransmitter 49 41.64 Quite Low
imagery 21 19.60 Low Low
sSRI 238 8.60 Low Low
Serotonin 77 5.00 Very Low Very Low Very Low
Catechol-O-methyltransferase 49 5.00 Very Low Very Low Very Low
behavioral therapy 49 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 1463 100.00 Very High Very High Very High
Autism 7 37.04 Quite Low
Congenital Anomalies 49 18.80 Low Low
Obsessive-compulsive Disorder 84 5.00 Very Low Very Low Very Low
Cognitive Disorder 63 5.00 Very Low Very Low Very Low
Tourette's Syndrome 63 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 63 5.00 Very Low Very Low Very Low
Chorea 35 5.00 Very Low Very Low Very Low
Streptococcal Infections 35 5.00 Very Low Very Low Very Low
Targeted Disruption 35 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In 2006, Arnold et al. [83] and Dickel et al. [84] simultaneously published independent studies demonstrating that variants in the solute carrier family 1, member 1 gene SLC1A1 are associated with OCD.
OCD Binding (associated) of SLC1A1 associated with anxiety disorder
1) Confidence 0.39 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.49 Pain Relevance 0.20
As detailed above, the most reliable evidence for gene association in OCD exists for the glutamate transporter gene SLC1A1, which together with recent reports of association for other genes directly involved in glutamatergic signaling at synapses has provoked a shift in attention to glutamatergic neurotransmission as a target for OCD pharmacotherapy.
OCD Binding (target) of SLC1A1 in synapses associated with glutamate and anxiety disorder
2) Confidence 0.39 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.95 Pain Relevance 0.05
An initial attempt failed to support association of SLC1A1 with OCD (but did confirm SLC1A1 as a positional candidate by mapping this gene within the 9p24 region) [90].
OCD Binding (association) of SLC1A1 associated with anxiety disorder
3) Confidence 0.34 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.43 Pain Relevance 0
This earlier negative result has been attributed to small sample size and incomplete coverage of the SLC1A1 gene region, and indeed association of SLC1A1 with OCD became apparent in a more thorough study by the same group in 2006 [84].
OCD Binding (association) of SLC1A1 associated with anxiety disorder
4) Confidence 0.34 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.48 Pain Relevance 0
Thus, considerable consistency has been established in the reported associations between SLC1A1 and OCD.
OCD Binding (associations) of SLC1A1 associated with anxiety disorder
5) Confidence 0.33 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.53 Pain Relevance 0
A third independent investigation [89] also confirmed an association between OCD and SLC1A1 for both single marker and haplotype single nucleotide polymorphisms (SNPs) in the 3’ region of the gene, consistent with the earlier studies [83, 84].
OCD Binding (association) of SLC1A1 associated with anxiety disorder
6) Confidence 0.33 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.50 Pain Relevance 0.10
As detailed above, the most reliable evidence for gene association in OCD exists for the glutamate transporter gene SLC1A1, which together with recent reports of association for other genes directly involved in glutamatergic signaling at synapses has provoked a shift in attention to glutamatergic neurotransmission as a target for OCD pharmacotherapy.
OCD Binding (association) of SLC1A1 in synapses associated with glutamate and anxiety disorder
7) Confidence 0.30 Published 2008 Journal Current Chemical Genomics Section Body Doc Link PMC2746669 Disease Relevance 0.85 Pain Relevance 0.05

General Comments

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