INT28254

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 8
Disease Relevance 3.92
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Aldh3a1) oxidoreductase activity (Aldh3a1) aging (Aldh3a1)
endoplasmic reticulum (Aldh3a1) cytoplasm (Aldh3a1)
Anatomy Link Frequency
hematopoietic stem cells 1
liver 1
Aldh3a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 52 99.44 Very High Very High Very High
agonist 1 76.56 Quite High
Nicotine 1 75.12 Quite High
tetrodotoxin 1 71.04 Quite High
sodium channel 1 67.44 Quite High
Calcium channel 1 65.84 Quite High
potassium channel 1 61.20 Quite High
Paracetamol 4 38.16 Quite Low
Enkephalin 1 25.00 Low Low
adenocard 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stress 122 98.24 Very High Very High Very High
Targeted Disruption 12 97.84 Very High Very High Very High
Brain Tumor 2 93.76 High High
Glioma 3 91.96 High High
Adrenal Cancer 1 89.68 High High
Malignant Neoplastic Disease 1 89.52 High High
Myeloid Leukemia 1 88.56 High High
Carcinoma 1 87.52 High High
Bladder Cancer 1 86.48 High High
Neuroblastoma 2 84.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NSCs, like hematopoietic stem cells, express high levels of aldehyde dehydrogenase (ALDH) as assessed by Aldefluor labeling.
Gene_expression (express) of ALDH in hematopoietic stem cells
1) Confidence 0.59 Published 2004 Journal J. Neurochem. Section Abstract Doc Link 14675165 Disease Relevance 0 Pain Relevance 0.24
SCHEME 1.Irreversible inactivation of ALDH-catalyzed GTN reduction.
Gene_expression (reduction) of ALDH
2) Confidence 0.31 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
Mitochondrial ALDH was
partially protected against GTN-induced inactivation by DTT and
LPA-H2, but not by GSH
(30). 
Neg (not) Gene_expression (protected) of Mitochondrial ALDH
3) Confidence 0.27 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2576553 Disease Relevance 0 Pain Relevance 0
EJ and FR3T3 cell lines also expressed the PPA mRNA, which was not detectable in A431, Y1, NS20Y, IMR32, HTC, HL60 cell lines as well as in the rat liver.
Neg (not) Gene_expression (detectable) of HTC in liver
4) Confidence 0.05 Published 1989 Journal Neuropeptides Section Abstract Doc Link 2739883 Disease Relevance 1.20 Pain Relevance 0
In addition, over-expression of the CpALDH gene confers tolerance to drought and salt stress in transgenic A. thaliana [34], and knockout mutations of selected members of class 3 ALDH genes are associated with abiotic stress sensitivity [5], [34], indicating that the ALDH gene superfamily can be used as genetic tools to engineer transgenic plants with enhanced environmental stress tolerance.
Gene_expression (-) of CpALDH associated with targeted disruption, stress and tolerance
5) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902511 Disease Relevance 0.73 Pain Relevance 0.09
The expression of many genes has recently been implicated in the complex desiccation-tolerant trait of C. plantagineum, and ALDH3 (CpALDH) was strongly expressed upon and throughout desiccation of the plant [15].
Gene_expression (expressed) of CpALDH
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902511 Disease Relevance 0.53 Pain Relevance 0.08
In addition, over-expression of the CpALDH gene confers tolerance to drought and salt stress in transgenic A. thaliana [34], and knockout mutations of selected members of class 3 ALDH genes are associated with abiotic stress sensitivity [5], [34], indicating that the ALDH gene superfamily can be used as genetic tools to engineer transgenic plants with enhanced environmental stress tolerance.
Gene_expression (over) of CpALDH associated with targeted disruption, stress and tolerance
7) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902511 Disease Relevance 0.73 Pain Relevance 0.09
In addition, over-expression of the CpALDH gene confers tolerance to drought and salt stress in transgenic A. thaliana [34], and knockout mutations of selected members of class 3 ALDH genes are associated with abiotic stress sensitivity [5], [34], indicating that the ALDH gene superfamily can be used as genetic tools to engineer transgenic plants with enhanced environmental stress tolerance.
Gene_expression (expression) of CpALDH associated with targeted disruption, stress and tolerance
8) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2902511 Disease Relevance 0.73 Pain Relevance 0.09

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