INT282543

Context Info Confidence 0.06 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.08 Pain Relevance 0.03

nucleus (KDM4C, POU5F1) cytosol (POU5F1) nucleoplasm (POU5F1) oxidoreductase activity (KDM4C) DNA binding (POU5F1) enzyme binding (KDM4C)

KDM4C (Homo sapiens) POU5F1 (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 2 64.16 tetrodotoxin 3 42.44 Potency 4 5.00 Action potential 3 5.00 Sciatic nerve 3 5.00 anesthesia 1 5.00 withdrawal 1 5.00

Disease Link Frequency Relevance Heat Adhesions 1 77.04 Obesity 4 50.00 Injury 1 5.76 Apoptosis 7 5.00 Death 4 5.00 Stress 3 5.00 Brain Injury 3 5.00 Targeted Disruption 2 5.00 Disease 2 5.00 Teratoma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Several genes are related to epigenetic regulation, including Jmjd1a and Jmjd2c which are downstream targets of Oct4 [20], [21].

Jmjd2c Regulation (targets) of Oct4

1) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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