INT282563

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Context Info
Confidence 0.27
First Reported 2009
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 2.36
Pain Relevance 0.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Nes) intracellular (Nes) cytoplasm (Nes)
Anatomy Link Frequency
neural 4
brains 2
Nes (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 8 92.72 High High
neurotrophin 3 16 88.24 High High
Hippocampus 74 84.08 Quite High
Central nervous system 30 75.60 Quite High
cytokine 8 39.00 Quite Low
Inflammation 4 38.60 Quite Low
chemokine 18 33.00 Quite Low
Pyramidal cell 2 8.64 Low Low
anesthesia 6 5.00 Very Low Very Low Very Low
Sciatic nerve 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Viral Infection 26 99.66 Very High Very High Very High
Infection 96 98.24 Very High Very High Very High
Cytomegalovirus Infection 112 96.96 Very High Very High Very High
Convulsion 88 95.96 Very High Very High Very High
Congenital Anomalies 2 95.28 Very High Very High Very High
Neurodegenerative Disease 36 95.12 Very High Very High Very High
Brain Injury 10 90.08 High High
Injury 12 74.08 Quite High
Status Epilepticus 38 63.48 Quite High
Age-related Macular Degeneration 10 59.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the transplanted population, we observed rapid differentiation, with a decline in nestin-expressing ESNPs within 1 week following injection into the DG.
Negative_regulation (decline) of Gene_expression (expressing) of nestin
1) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.10 Pain Relevance 0.03
Within one week following transplantation into the DG, a majority of the transplanted ESNPs showed loss of nestin expression, suggesting that they had differentiated (Figure 6A, G).
Negative_regulation (loss) of Gene_expression (expression) of nestin
2) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.58 Pain Relevance 0.04
Relatively low levels of nestin expression were detected in infected-brains by flow cytometry (Fig 3C).
Negative_regulation (levels) of Gene_expression (expression) of nestin in brains
3) Confidence 0.24 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.76 Pain Relevance 0
Additionally, viral infection caused a marked loss of NSCs expressing CD133 and nestin.
Negative_regulation (loss) of Gene_expression (expressing) of nestin associated with viral infection
4) Confidence 0.21 Published 2011 Journal PLoS ONE Section Body Doc Link PMC3020957 Disease Relevance 0.67 Pain Relevance 0.19
Extremely down-regulated Nestin expression was observed in Oct4-induced neural cells after induction (data not showed).
Negative_regulation (regulated) of Gene_expression (expression) of Nestin in neural
5) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.25 Pain Relevance 0.05
After neural induction in differentiated Oct4/ATSCs, we observed an extreme upregulation of TuJ and MAP2ab and low levels of Nestin expression in Oct4/ATSCs after neural differentiation and also neurosphere formation efficiency was higher than control ATSCs (Fig. 6A).
Negative_regulation (levels) of Gene_expression (expression) of Nestin in neural
6) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0 Pain Relevance 0.05

General Comments

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