INT282568

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Context Info
Confidence 0.34
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.95
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (Cdk2) cytoplasm (Cdk2) cytosol (Cdk2)
mitosis (Cdk2) nucleus (Cdk2) cytoskeleton (Cdk2)
Anatomy Link Frequency
IEC-6 1
telomere 1
Cdk2 (Mus musculus)
Pain Link Frequency Relevance Heat
Potency 7 61.28 Quite High
Crohn's disease 2 11.48 Low Low
Inflammation 5 5.00 Very Low Very Low Very Low
Mechanosensation 4 5.00 Very Low Very Low Very Low
Somatostatin 4 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 23 99.62 Very High Very High Very High
Apoptosis 122 97.82 Very High Very High Very High
Cancer 284 89.96 High High
Targeted Disruption 12 83.84 Quite High
Polycystic Kidney Disease 62 80.32 Quite High
Aging 1 78.32 Quite High
Toxicity 12 72.56 Quite High
Syndrome 7 70.24 Quite High
Cyst 32 66.88 Quite High
Congenital Anomalies 6 56.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
UTR (corresponding to nt 1180–2606 of the Entrez PubMed transcript BC095407) was PCR amplified from a pBluescriptR vector containing CREB1 full length cDNA (Open Biosystems); The PCR products were cloned into pGL3-control luciferase reporter vector (Promega) via an XbaI restriction site, immediately downstream of the luciferase gene; a 38 bp fragment of the human CDK2 mRNA 3?
Positive_regulation (fragment) of CDK2
1) Confidence 0.34 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
Maddika et al indicated that inhibitors of PI3-kinase or Akt not only inhibited CDK2 activation but also protected cells from Apoptin-induced cell death, and Akt-mediated activation of CDK2 was caused by direct phosphorylation as well as by the phosphorylation-induced degradation of its inhibitor p27 (Kip1) [32].
Positive_regulation (activation) of CDK2 associated with death
2) Confidence 0.26 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.87 Pain Relevance 0
Maddika et al indicated that inhibitors of PI3-kinase or Akt not only inhibited CDK2 activation but also protected cells from Apoptin-induced cell death, and Akt-mediated activation of CDK2 was caused by direct phosphorylation as well as by the phosphorylation-induced degradation of its inhibitor p27 (Kip1) [32].
Positive_regulation (activation) of CDK2 associated with death
3) Confidence 0.26 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.93 Pain Relevance 0
Recently, it was shown that Apoptin-induced apoptosis essentially depends on abnormal phosphatidylinositol 3-kinase (PI3-kinase)/Akt activation, resulting in the activation of the cyclin-dependent kinase CDK2 [32].
Positive_regulation (activation) of CDK2 associated with apoptosis
4) Confidence 0.24 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 0.83 Pain Relevance 0
Immunoblotting of IEC-6 cells demonstrated that CCNE1, CDK2, CREB1 are induced at the protein level upon miR-103 inhibition, further supporting an effect of miR-103 regulation on these genes.
Positive_regulation (induced) of CDK2 in IEC-6
5) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2944884 Disease Relevance 0 Pain Relevance 0
The translocation of Id2 in cells with mutated polycystins is associated with downregulation of p21 expression, leading to an increase in CDK2 activity and cell cycle progression (Fig. 3).
Positive_regulation (increase) of CDK2
6) Confidence 0.16 Published 2007 Journal Cell Mol Life Sci Section Body Doc Link PMC2775119 Disease Relevance 0.25 Pain Relevance 0
The Oct4-overexpressed ATSC cells showed prominent effects on upregulation of a variety of proliferation-associated genes, including RUNX3, CDK2 and CDK4, and telomere reverse transcriptase (TERT; Fig. 1D).
Positive_regulation (upregulation) of CDK2 in telomere
7) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.08 Pain Relevance 0.03

General Comments

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