INT282576

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Context Info
Confidence 0.43
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 12
Total Number 14
Disease Relevance 2.79
Pain Relevance 0.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1)
DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)
Anatomy Link Frequency
endometrium 4
embryos 2
testes 2
germ cells 2
POU5F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 12 91.68 High High
Hippocampus 8 89.24 High High
Potency 19 69.76 Quite High
Inflammation 102 50.00 Quite Low
pain pelvic 8 46.80 Quite Low
Dismenorea 8 44.24 Quite Low
cytokine 54 5.00 Very Low Very Low Very Low
Action potential 27 5.00 Very Low Very Low Very Low
tetrodotoxin 16 5.00 Very Low Very Low Very Low
Spinal cord 15 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Endometriosis (extended) 20 100.00 Very High Very High Very High
Carcinoma In Situ 8 95.38 Very High Very High Very High
Targeted Disruption 10 94.52 High High
Hypoxia 37 93.16 High High
Repression 4 92.72 High High
Malignant Neoplastic Disease 12 87.64 High High
Testicular Cancer 4 85.80 High High
Congenital Anomalies 14 82.64 Quite High
Injury 20 82.08 Quite High
Syndrome 22 81.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Such experiments may determine whether or not endometrial expression of OCT-4 - as demonstrated in this study - will decrease at the end of the reproductive period.
Spec (whether) Negative_regulation (decrease) of Gene_expression (expression) of OCT-4
1) Confidence 0.43 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.15 Pain Relevance 0.05
Loss of OCT-4 expression may be associated with the loss of pluripotentiality [5].
Negative_regulation (Loss) of Gene_expression (expression) of OCT-4
2) Confidence 0.43 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.40 Pain Relevance 0
This rejects our study hypothesis that OCT-4 is overexpressed during endometrial proliferation in the follicular phase and downregulated during the secretory transformation of the endometrium in the luteal phase.
Negative_regulation (downregulated) of Gene_expression (overexpressed) of OCT-4 in endometrium associated with endometriosis (extended)
3) Confidence 0.43 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.10 Pain Relevance 0
In the present study we assessed the mRNA levels and protein expression of OCT-4 in human endometrium.
Negative_regulation (assessed) of Gene_expression (expression) of OCT-4 in endometrium
4) Confidence 0.43 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0
Downregulation of Oct4 expression during trophoblast differentiation, the generation of mutant embryos, and conversion into exclusively trophoblast-like cells after Oct4 knockout revealed that the transcription factor, Oct4 was required to either establish or maintain pluripotency in the developmental embryo.
Negative_regulation (Downregulation) of Gene_expression (expression) of Oct4 in embryos associated with targeted disruption
5) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.09 Pain Relevance 0.04
Among these miRNAs, 208 were significantly up- or downregulated in Oct4 overexpressed ATSCs (p<0.00032).
Negative_regulation (downregulated) of Gene_expression (overexpressed) of Oct4
6) Confidence 0.39 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0 Pain Relevance 0
We evaluated the expression of Oct4 (POU5F1) to determine whether exogenic Oct4 induced the expression of early developmental genes KLF4, Sox-2, Rex-1, Utf1, Dapp5, FGF4, ERas, and Nanog in cultured ATSCs (Fig. 1E).
Negative_regulation (evaluated) of Gene_expression (expression) of Oct4
7) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.18 Pain Relevance 0.03
We evaluated the expression of Oct4 (POU5F1) to determine whether exogenic Oct4 induced the expression of early developmental genes KLF4, Sox-2, Rex-1, Utf1, Dapp5, FGF4, ERas, and Nanog in cultured ATSCs (Fig. 1E).
Negative_regulation (evaluated) of Gene_expression (expression) of POU5F1
8) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.18 Pain Relevance 0.03
siRNA transfection prominently induced downregulated stemness genes expression, such as Rex1, Sox2, Oct4, and Klf4 with prominent growth attenuation (Figure 3E, 3F).


Negative_regulation (downregulated) of Gene_expression (expression) of Oct4
9) Confidence 0.35 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.49 Pain Relevance 0
The % of cells expressing OCT4 after grafting was significantly reduced when compared with the pre-graft control tissue for both first and second trimester testes, while the % of cells expressing VASA significantly increased in the first-trimester grafts, compared with the pre-graft control.
Negative_regulation (reduced) of Gene_expression (expressing) of OCT4 in testes
10) Confidence 0.33 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
CIS cells are thought to originate because of failure of normal differentiation of fetal germ cells into prespermatogonia (Rajpert-De Meyts, 2006), a process that encompasses fetal and early post-natal life in humans and involves the loss of expression of pluripotency factors (OCT4 and NANOG) and expression of proteins indicative of differentiation (VASA and MAGE-A4) (Gaskell et al., 2004; Anderson et al., 2007; Mitchell et al., 2008).
Negative_regulation (loss) of Gene_expression (expression) of OCT4 in germ cells associated with carcinoma in situ
11) Confidence 0.33 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 1.05 Pain Relevance 0
Through RT-PCR (Figure 1C), we confirmed that expression of the pluripotency genes POU5F1 (OCT4) and NANOG decreased starting at day 6 of differentiation from either hESC (H9) or hiPSC (YZ1).
Negative_regulation (decreased) of Gene_expression (expression) of OCT4
12) Confidence 0.33 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912324 Disease Relevance 0 Pain Relevance 0
Treatment with IL-6 neutralizing antibody decreased the basal level of hTERT and Oct-4, and in conjunction with IL-17 antibody only slightly augmented the blockade of hTERT and Oct-4 expression in both SKPs and KPCs (Figure 5C).
Negative_regulation (blockade) of Gene_expression (expression) of Oct-4
13) Confidence 0.13 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.08 Pain Relevance 0
Our results indicated that IL-17-induced hTERT and Oct-4 expression was abolished by pretreatment with neutralizing antibody for either IL-17, or IL-6, or both (Figure 5D).
Negative_regulation (abolished) of Gene_expression (expression) of Oct-4
14) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2771422 Disease Relevance 0.07 Pain Relevance 0

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