INT282585

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.08
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1)
DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)
Anatomy Link Frequency
germ cells 1
fibroblasts 1
POU5F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 4 5.00 Very Low Very Low Very Low
Sciatic nerve 3 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
adenocard 3 5.00 Very Low Very Low Very Low
Action potential 3 5.00 Very Low Very Low Very Low
Hippocampus 2 5.00 Very Low Very Low Very Low
Spinal cord 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Chromosome Aberrations 1 78.56 Quite High
Obesity 5 50.00 Quite Low
Retinal Diseases 11 49.76 Quite Low
Apoptosis 8 47.48 Quite Low
Stress 7 45.60 Quite Low
Death 5 44.64 Quite Low
Age-related Macular Degeneration 64 23.52 Low Low
Retina Disease 17 23.20 Low Low
Disease 58 5.00 Very Low Very Low Very Low
Ocular Toxicity (including Many Sub-types) 14 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The proliferation of Oct4/ATSCs is promoted significantly by supplementation of exogenic Oct4 with highly improved transdifferentiation activity.
Localization (proliferation) of Oct4
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.08 Pain Relevance 0
FigureĀ 4(A) Immunoexpression (brown) of OCT4 (top), VASA (middle) and MAGE-A4 (bottom) in germ cells in a first trimester human testis prior to grafting (Pre-graft control) and 6 weeks after grafting into a mouse host (graft).
Localization (grafting) of OCT4 in germ cells
2) Confidence 0.66 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0
This work was soon supplemented by the generation of human iPSCs by two groups, one of whom [186] showed that adult human dermal fibroblasts can also be reprogrammed by overexpression of OCT4, SOX2, KLF4, and c-MYC, while another [188] made use of a slightly different set of factors (OCT4, SOX2, LIN28, and NANOG) to reprogram both fetal and adult human fibroblasts.
Localization (generation) of OCT4 in fibroblasts
3) Confidence 0.21 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

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