INT282585

Context Info Confidence 0.67 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 0.08 Pain Relevance 0

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1) DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)

Anatomy Link Frequency germ cells 1 fibroblasts 1 POU5F1 (Homo sapiens)

Pain Link Frequency Relevance Heat Potency 4 5.00 Sciatic nerve 3 5.00 tetrodotoxin 3 5.00 Inflammation 3 5.00 adenocard 3 5.00 Action potential 3 5.00 Hippocampus 2 5.00 Spinal cord 1 5.00 Central nervous system 1 5.00 anesthesia 1 5.00

Disease Link Frequency Relevance Heat Chromosome Aberrations 1 78.56 Obesity 5 50.00 Retinal Diseases 11 49.76 Apoptosis 8 47.48 Stress 7 45.60 Death 5 44.64 Age-related Macular Degeneration 64 23.52 Retina Disease 17 23.20 Disease 58 5.00 Ocular Toxicity (including Many Sub-types) 14 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The proliferation of Oct4/ATSCs is promoted significantly by supplementation of exogenic Oct4 with highly improved transdifferentiation activity.

Localization (proliferation) of Oct4

1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.08 Pain Relevance 0

Figure 4(A) Immunoexpression (brown) of OCT4 (top), VASA (middle) and MAGE-A4 (bottom) in germ cells in a first trimester human testis prior to grafting (Pre-graft control) and 6 weeks after grafting into a mouse host (graft).

Localization (grafting) of OCT4 in germ cells

2) Confidence 0.66 Published 2010 Journal Human Reproduction (Oxford, England) Section Body Doc Link PMC2939754 Disease Relevance 0 Pain Relevance 0

This work was soon supplemented by the generation of human iPSCs by two groups, one of whom [186] showed that adult human dermal fibroblasts can also be reprogrammed by overexpression of OCT4, SOX2, KLF4, and c-MYC, while another [188] made use of a slightly different set of factors (OCT4, SOX2, LIN28, and NANOG) to reprogram both fetal and adult human fibroblasts.

Localization (generation) of OCT4 in fibroblasts

3) Confidence 0.21 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.