INT282590

Context Info Confidence 0.70 First Reported 2009 Last Reported 2010 Negated 2 Speculated 2 Reported most in Body Documents 40 Total Number 44 Disease Relevance 8.42 Pain Relevance 1.32

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1) DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)

Anatomy Link Frequency fibroblasts 6 telomere 6 germ cells 4 endometrium 4 fat 2 POU5F1 (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 213 89.00 pain pelvic 20 81.92 Dismenorea 20 79.36 endometriosis 30 78.56 Potency 95 74.12 Spinal cord 63 59.20 withdrawal 25 51.52 cytokine 108 45.12 Action potential 80 5.32 Sciatic nerve 75 5.00

Disease Link Frequency Relevance Heat Endometriosis (extended) 50 99.68 Keloid Scars 412 99.36 Disease 282 98.80 Obesity 121 95.92 Apoptosis 171 95.60 Hypoxia 179 93.48 Death 113 92.76 Aging 74 92.76 Cancer 137 92.68 Diabetes Mellitus 63 90.64

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Increased mRNA levels and increased OCT-4 protein expression were significantly correlated (Pearson's correlation coefficient 0.8).

Positive_regulation (increased) of Gene_expression (expression) of OCT-4 protein

1) Confidence 0.70 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.31 Pain Relevance 0.16

This rejects our study hypothesis that OCT-4 is overexpressed during endometrial proliferation in the follicular phase and downregulated during the secretory transformation of the endometrium in the luteal phase.

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of OCT-4 in endometrium associated with endometriosis (extended)

2) Confidence 0.70 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.10 Pain Relevance 0

Increased mRNA levels and increased OCT-4 protein expression were significantly correlated (Pearson's correlation coefficient 0.8).

Positive_regulation (Increased) of Gene_expression (expression) of OCT-4 protein

3) Confidence 0.70 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.32 Pain Relevance 0.16

Figure 3 shows follicular and luteal phase endometrial samples with and without OCT-4 overexpression.

Neg (without) Positive_regulation (overexpression) of Gene_expression (overexpression) of OCT-4

4) Confidence 0.70 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.27 Pain Relevance 0.14

OCT-4 protein overexpression in the follicular and luteal phase was found in 33/49 (67%) and 23/40 (58%) of women, respectively (p = 0.5).

Positive_regulation (overexpression) of Gene_expression (overexpression) of OCT-4 protein

5) Confidence 0.70 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.38 Pain Relevance 0.19

OCT-4 protein overexpression was identified in 56/89 (63%) samples.

Positive_regulation (overexpression) of Gene_expression (overexpression) of OCT-4 protein

6) Confidence 0.70 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.39 Pain Relevance 0.20

Oct4 overexpression in ATSC as evidenced by various cell reprogramming behaviors via the expression of stemness genes

Positive_regulation (overexpression) of Gene_expression (overexpression) of Oct4

7) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.16 Pain Relevance 0

We studied the effect of Oct4 overexpression on mesodermal lineage differentiation into fat, bone, and chondrocyte of ATSCs.

Positive_regulation (overexpression) of Gene_expression (overexpression) of Oct4 in fat

8) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.09 Pain Relevance 0

In our study, Oct4/ATSCs overexpress not only Oct4, Sox-2, Nanog, and Rex1, but also c-Myc to obtain active self-renewal activity with pluripotency after exogenic Oct4 transfection.

Positive_regulation (overexpress) of Gene_expression (overexpress) of Oct4

9) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.22 Pain Relevance 0

When Oct4 expression was recovered by exogenic Oct4 gene overexpression in damaged cells, ATSCs recovered to normal and viable cell with cell survival related signal pathway molecule such as Akt/PI3K, Bcl2, and ERK1/2.

Positive_regulation (overexpression) of Gene_expression (overexpression) of Oct4

10) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.28 Pain Relevance 0

Our results showed that Oct4/ATSC can increase developmental potential following reprogramming via the overexpression of the embryonic transcription factors, Rex1, Oct4, and Oct4-dependent Nanog and Sox2.

Positive_regulation (overexpression) of Gene_expression (overexpression) of Oct4

11) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.23 Pain Relevance 0

The Oct4-overexpressed ATSC cells showed prominent effects on upregulation of a variety of proliferation-associated genes, including RUNX3, CDK2 and CDK4, and telomere reverse transcriptase (TERT; Fig. 1D).

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Oct4 in telomere

12) Confidence 0.62 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.13 Pain Relevance 0.03

In a univariate regression model, the day of the menstrual cycle, using 3-day intervals, did not influence OCT-4 protein expression, when comparing an IRS <6 vs. ?

Neg (not) Positive_regulation (influence) of Gene_expression (expression) of OCT-4 protein

13) Confidence 0.50 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.33 Pain Relevance 0.17

Specifically, we aimed to answer the question whether or not OCT-4 is overexpressed during endometrial proliferation in the follicular phase and downregulated during the secretory transformation of the endometrium in the luteal phase.

Spec (whether) Positive_regulation (overexpressed) of Gene_expression (overexpressed) of OCT-4 in endometrium associated with endometriosis (extended)

14) Confidence 0.47 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.18 Pain Relevance 0

Increased expression of OCT-4 protein in the follicular and luteal phases was found in 33/49 (67%) and 23/40 (58%) of women, respectively (p = 0.5).

Positive_regulation (Increased) of Gene_expression (expression) of OCT-4 protein

15) Confidence 0.47 Published 2010 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0

Increased expression of OCT-4 protein was identified in 56/89 (63%) samples.

Positive_regulation (Increased) of Gene_expression (expression) of OCT-4 protein

16) Confidence 0.47 Published 2010 Journal Reprod Biol Endocrinol Section Abstract Doc Link PMC2867815 Disease Relevance 0 Pain Relevance 0

And Oct4/ATSCs overexpressed the oncogenic gene, c-myc with prominently extended the S phase in cell cycles (Fig. 1C).

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Oct4

17) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.16 Pain Relevance 0

Evaluation of trans-differentiation properties of Oct4 overexpressed cells in vitro and in vivo BT mouse model

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Oct4

18) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0 Pain Relevance 0

Differential expression of selected genes was verified independently using real time PCR and prepared from Oct4 overexpressed ATSCs or control ATSCs (Fig. 4).

Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Oct4

19) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0 Pain Relevance 0

The inhibition of ATSC growth was detected by transfection of Oct4 siRNA into ATSCs cells and counted dye-exclusive viable cells for 6 days.

Positive_regulation (transfection) of Gene_expression (transfection) of Oct4

20) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.32 Pain Relevance 0

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