INT282592

Context Info Confidence 0.26 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0.03

nucleolus (KLF4) nucleus (KLF4) intracellular (KLF4) DNA binding (KLF4)

Anatomy Link Frequency stem cells 1 KLF4 (Homo sapiens)

Pain Link Frequency Relevance Heat Action potential 3 52.32 Potency 4 5.00 tetrodotoxin 3 5.00 Sciatic nerve 3 5.00 Hippocampus 2 5.00 anesthesia 1 5.00 withdrawal 1 5.00

Disease Link Frequency Relevance Heat Obesity 4 75.00 Apoptosis 7 5.00 Death 4 5.00 Stress 3 5.00 Brain Injury 3 5.00 Targeted Disruption 2 5.00 Disease 2 5.00 Teratoma 2 5.00 Adhesions 1 5.00 Chromosome Aberrations 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Global gene expression analysis results showed that Oct4 regulated target genes which could be characterized as differentially regulated genes such as pluripotency markers NANOG, SOX2, and KLF4 and markers of undifferentiated stem cells FOXD1, CDC2, and EPHB1.

Regulation (regulated) of KLF4 in stem cells

1) Confidence 0.26 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2747014 Disease Relevance 0.14 Pain Relevance 0.03

General Comments

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