INT2826

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Context Info
Confidence 0.37
First Reported 1979
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 6
Total Number 6
Disease Relevance 0.90
Pain Relevance 1.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
skin 2
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 6 99.98 Very High Very High Very High
cINOD 12 99.12 Very High Very High Very High
diclofenac 1 81.80 Quite High
antagonist 4 77.44 Quite High
Calcitonin gene-related peptide 1 76.12 Quite High
Inflammation 4 75.00 Quite High
Potency 1 74.16 Quite High
Migraine 1 61.08 Quite High
ischemia 1 60.36 Quite High
tissue acidosis 1 58.48 Quite High
Disease Link Frequency Relevance Heat
Glioma 2 97.76 Very High Very High Very High
INFLAMMATION 9 93.32 High High
Headache 1 61.08 Quite High
Cv Unclassified Under Development 2 60.36 Quite High
Acidosis 1 58.48 Quite High
Pressure And Volume Under Development 2 25.00 Low Low
Burns 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: EMLA cream induced a significant inhibition of TXB2 (P<0.05) and 6-Keto-PGF1alpha (P<0.01) but not of PGE release from burned skin as compared to saline treatment.
Negative_regulation (inhibition) of Localization (release) of PGE in skin
1) Confidence 0.37 Published 1999 Journal Acta Anaesthesiol Scand Section Body Doc Link 10408815 Disease Relevance 0 Pain Relevance 0
Aspirin suppressed PGE and F release from non-inflamed and inflamed synovial membrane in vivo and in vitro, but suppression of PGF release was more intense.
Negative_regulation (suppressed) of Localization (release) of PGE associated with aspirin
2) Confidence 0.37 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 544394 Disease Relevance 0.24 Pain Relevance 0.28
Hydrocortisone suppressed release of PGE and F from inflamed synovial membrane in vivo, and did not influence PG release in vitro.
Negative_regulation (suppressed) of Localization (release) of PGE
3) Confidence 0.37 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 544394 Disease Relevance 0.24 Pain Relevance 0.28
The excretion of urinary PGE was significantly decreased by administration of NSAID.
Negative_regulation (decreased) of Localization (excretion) of PGE associated with cinod
4) Confidence 0.16 Published 1980 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 6781993 Disease Relevance 0.07 Pain Relevance 0.78
The proton-reduction of PGE(2) release was overcome by adding ATP (10(-3)M).
Negative_regulation (reduction) of Localization (release) of PGE
5) Confidence 0.04 Published 2002 Journal Pain Section Abstract Doc Link 12044622 Disease Relevance 0.18 Pain Relevance 0.29
An 18-h treatment with gamma-mangostin potently inhibited spontaneous PGE(2) release in a concentration-dependent manner with the IC(50) value of approximately 2 microM, without affecting the cell viability even at 30 microM.
Negative_regulation (inhibited) of Localization (release) of PGE
6) Confidence 0.02 Published 2004 Journal Mol. Pharmacol. Section Abstract Doc Link 15322259 Disease Relevance 0.17 Pain Relevance 0

General Comments

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