INT282605

Context Info Confidence 0.55 First Reported 2009 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 4 Total Number 4 Disease Relevance 0.40 Pain Relevance 0

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1) DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)

Anatomy Link Frequency bone marrow 1 POU5F1 (Homo sapiens)

Pain Link Frequency Relevance Heat Hippocampus 6 40.72 tetrodotoxin 9 19.00 Potency 12 5.00 Action potential 9 5.00 Sciatic nerve 9 5.00 anesthesia 3 5.00 withdrawal 3 5.00 endometriosis 3 5.00 pain pelvic 2 5.00 Dismenorea 2 5.00

Disease Link Frequency Relevance Heat Adhesions 3 90.08 Congenital Anomalies 1 88.44 Endometriosis (extended) 5 87.84 Osteoporosis 3 80.48 Cancer 2 54.16 Obesity 12 50.00 Breast Cancer 1 42.60 Carcinoma 2 41.08 Germ Cell And Embryonal Neoplasms 1 40.24 Malignant Neoplastic Disease 1 38.92

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Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

The mechanisms involved in the Oct4 regulation in ES have been widely investigated, but the adult stage (including postnatal and fetus stages) of Oct4 function has not been identified even though it had recently been associated with the undifferentiated pluripotent state of stem cell populations derived from various adult human tissues or organs such as bone marrow-derived multipotent adult progenitor cells.

Regulation (regulation) of Oct4 in bone marrow

1) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.09 Pain Relevance 0

To confirm the negatively regulated downstream targets of Oct4, the profile analysis was repeated for BMP4.

Regulation (targets) of Oct4

2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0 Pain Relevance 0

To validate the results of our miRNA array analysis, 6 miRNAs were selected as up- and down-regulated miRNAs in Oct4 transfected ATSC cells by real time RT-PCR.

Regulation (regulated) of Oct4

3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.08 Pain Relevance 0

We hypothesized that OCT-4 is differentially regulated in the follicular and luteal phases of the menstrual cycle.

Regulation (regulated) of OCT-4

4) Confidence 0.27 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.23 Pain Relevance 0

General Comments

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