INT282605

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Context Info
Confidence 0.55
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 0.40
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1)
DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)
Anatomy Link Frequency
bone marrow 1
POU5F1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 6 40.72 Quite Low
tetrodotoxin 9 19.00 Low Low
Potency 12 5.00 Very Low Very Low Very Low
Action potential 9 5.00 Very Low Very Low Very Low
Sciatic nerve 9 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
endometriosis 3 5.00 Very Low Very Low Very Low
pain pelvic 2 5.00 Very Low Very Low Very Low
Dismenorea 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adhesions 3 90.08 High High
Congenital Anomalies 1 88.44 High High
Endometriosis (extended) 5 87.84 High High
Osteoporosis 3 80.48 Quite High
Cancer 2 54.16 Quite High
Obesity 12 50.00 Quite Low
Breast Cancer 1 42.60 Quite Low
Carcinoma 2 41.08 Quite Low
Germ Cell And Embryonal Neoplasms 1 40.24 Quite Low
Malignant Neoplastic Disease 1 38.92 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mechanisms involved in the Oct4 regulation in ES have been widely investigated, but the adult stage (including postnatal and fetus stages) of Oct4 function has not been identified even though it had recently been associated with the undifferentiated pluripotent state of stem cell populations derived from various adult human tissues or organs such as bone marrow-derived multipotent adult progenitor cells.
Regulation (regulation) of Oct4 in bone marrow
1) Confidence 0.55 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.09 Pain Relevance 0
To confirm the negatively regulated downstream targets of Oct4, the profile analysis was repeated for BMP4.
Regulation (targets) of Oct4
2) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0 Pain Relevance 0
To validate the results of our miRNA array analysis, 6 miRNAs were selected as up- and down-regulated miRNAs in Oct4 transfected ATSC cells by real time RT-PCR.


Regulation (regulated) of Oct4
3) Confidence 0.35 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.08 Pain Relevance 0
We hypothesized that OCT-4 is differentially regulated in the follicular and luteal phases of the menstrual cycle.
Regulation (regulated) of OCT-4
4) Confidence 0.27 Published 2010 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2867815 Disease Relevance 0.23 Pain Relevance 0

General Comments

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