INT282606

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Context Info
Confidence 0.54
First Reported 2009
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.80
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (KLF4) nucleus (KLF4) intracellular (KLF4)
DNA binding (KLF4)
Anatomy Link Frequency
fibroblasts 6
KLF4 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 7 77.20 Quite High
Spinal cord 15 5.00 Very Low Very Low Very Low
adenocard 9 5.00 Very Low Very Low Very Low
Inflammation 9 5.00 Very Low Very Low Very Low
Action potential 7 5.00 Very Low Very Low Very Low
Sciatic nerve 6 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
tetrodotoxin 3 5.00 Very Low Very Low Very Low
interneuron 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypoxia 35 93.48 High High
Injury 5 82.88 Quite High
Wound Healing 2 72.64 Quite High
Aging 19 69.32 Quite High
Retinal Diseases 33 62.76 Quite High
Severe Combined Immunodeficiency 10 62.24 Quite High
Teratoma 3 59.28 Quite High
Obesity 13 50.00 Quite Low
Disease 172 39.92 Quite Low
Age-related Macular Degeneration 192 36.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This work was soon supplemented by the generation of human iPSCs by two groups, one of whom [186] showed that adult human dermal fibroblasts can also be reprogrammed by overexpression of OCT4, SOX2, KLF4, and c-MYC, while another [188] made use of a slightly different set of factors (OCT4, SOX2, LIN28, and NANOG) to reprogram both fetal and adult human fibroblasts.
Positive_regulation (overexpression) of Gene_expression (overexpression) of KLF4 in fibroblasts
1) Confidence 0.54 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0 Pain Relevance 0
This process, which is held as one of the most seminal discoveries in the stem cell field, was first reported by Yamanaka's group [187] and involves overexpression of four key genes (Oct4, Sox2, Klf4, and c-Myc) in murine fibroblasts, resulting in their conversion into cells that resemble ESCs in terms of morphology, gene expression, growth, and differentiation capabilities and are now named induced pluripotent stem cells (iPSCs).
Positive_regulation (overexpression) of Gene_expression (overexpression) of Klf4 in fibroblasts
2) Confidence 0.39 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0.06 Pain Relevance 0
Since these initial papers there has been remarkable progress in the field, aimed largely at increasing the efficiency of the iPSC generation protocol and replacing the initial retroviral vectors that were used to transfect fibroblasts with OCT4, SOX2, KLF4, and c-MYC.
Positive_regulation (transfect) of Gene_expression (transfect) of KLF4 in fibroblasts
3) Confidence 0.39 Published 2009 Journal Stem Cells (Dayton, Ohio) Section Body Doc Link PMC2962903 Disease Relevance 0 Pain Relevance 0
We evaluated the expression of Oct4 (POU5F1) to determine whether exogenic Oct4 induced the expression of early developmental genes KLF4, Sox-2, Rex-1, Utf1, Dapp5, FGF4, ERas, and Nanog in cultured ATSCs (Fig. 1E).
Spec (whether) Positive_regulation (induced) of Gene_expression (expression) of KLF4
4) Confidence 0.22 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2747014 Disease Relevance 0.24 Pain Relevance 0.04
siRNA transfection prominently induced downregulated stemness genes expression, such as Rex1, Sox2, Oct4, and Klf4 with prominent growth attenuation (Figure 3E, 3F).


Positive_regulation (induced) of Gene_expression (expression) of Klf4
5) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2817727 Disease Relevance 0.49 Pain Relevance 0

General Comments

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