INT282732

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Context Info
Confidence 0.06
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 2.09
Pain Relevance 0.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mtor) mitochondrion (Mtor) Golgi apparatus (Mtor)
endoplasmic reticulum (Mtor) nucleus (Mtor) kinase activity (Mtor)
Mtor (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 72 99.08 Very High Very High Very High
Kinase C 1 98.48 Very High Very High Very High
Inflammation 2 98.36 Very High Very High Very High
cerebral cortex 20 5.00 Very Low Very Low Very Low
Clonidine 7 5.00 Very Low Very Low Very Low
cva 5 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Versed 3 5.00 Very Low Very Low Very Low
abdominal pain 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Insulin Resistance 25 99.14 Very High Very High Very High
Cv Unclassified Under Development 70 99.08 Very High Very High Very High
INFLAMMATION 2 98.36 Very High Very High Very High
Apoptosis 2 96.36 Very High Very High Very High
Hypoxia 12 95.00 High High
Targeted Disruption 11 89.12 High High
Stress 73 87.24 High High
Shock 2 83.76 Quite High
Gastrointestinal Stromal Tumor 67 68.80 Quite High
Cancer 80 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The mTOR phosphorylation at Ser2448 (and Ser2481 autophosphorylation) and 4E-BP1 phosphorylation were restored during reperfusion and returned to control values.
Positive_regulation (restored) of Phosphorylation (phosphorylation) of mTOR
1) Confidence 0.06 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.05
The mTOR phosphorylation at Ser2448 (and Ser2481 autophosphorylation) and 4E-BP1 phosphorylation were restored during reperfusion and returned to control values.
Positive_regulation (restored) of Phosphorylation (phosphorylation) of mTOR
2) Confidence 0.04 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2966049 Disease Relevance 0.35 Pain Relevance 0.05
In a number of studies, long chain saturated fatty acids have been shown to induce insulin resistance by activation of pathways involved in inflammation that intersect with insulin resistance such as the Toll-like receptor 4 mediated activation of NF-kB, as well as hyperphosphorylation of protein kinases like mammalian target of rapamycin (mTOR), c-jun N-terminal kinase (JNK), and protein kinase C isoforms [20-22].
Positive_regulation (activation) of Phosphorylation (hyperphosphorylation) of mTOR associated with kinase c, inflammation and insulin resistance
3) Confidence 0.03 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2852377 Disease Relevance 0.67 Pain Relevance 0.10
Since phosphorylation of mTOR depends on KIT signaling in the imatinib-sensitive GISTs, RAD001 did not show any synergistic effect with imatinib in this setting.
Positive_regulation (depends) of Phosphorylation (phosphorylation) of mTOR
4) Confidence 0.03 Published 2009 Journal World J Surg Oncol Section Body Doc Link PMC2749031 Disease Relevance 0.72 Pain Relevance 0
(A) Vitamin E increases phosphorylation of mTOR substrates.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of mTOR
5) Confidence 0.02 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0 Pain Relevance 0

General Comments

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