INT282775

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.28
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CD4) cell adhesion (CD4) plasma membrane (CD4)
enzyme binding (CD4)
Anatomy Link Frequency
T cell 4
CD4 (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 56 99.78 Very High Very High Very High
Inflammation 14 86.96 High High
Arthritis 1 59.04 Quite High
cytokine 16 19.36 Low Low
headache 5 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
withdrawal 3 5.00 Very Low Very Low Very Low
psoriasis 2 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
corticosteroid 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 56 99.78 Very High Very High Very High
Genetic Predisposition To Disease 1 97.12 Very High Very High Very High
Disease 11 87.28 High High
INFLAMMATION 14 86.96 High High
Malaria 20 85.44 High High
Immunization 18 83.40 Quite High
Apoptosis 24 80.08 Quite High
Arthritis 2 59.04 Quite High
Death 7 46.08 Quite Low
Erythema 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As the shared epitope in human leukocyte antigen-DR genes is found in about 80% of RA patients, dysregulated CD4+ T cell activation and function have been investigated based on the available evidence of genetic predisposition [2,3].
Regulation (dysregulated) of Positive_regulation (activation) of CD4 in T cell associated with genetic predisposition to disease and rheumatoid arthritis
1) Confidence 0.37 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2911863 Disease Relevance 1.05 Pain Relevance 0.30
The frequency of PfCS specific CD4+ and CD8+ T cells was evaluated by ICS in HLA-A2 and HLA-A3 volunteers (n?
Regulation (evaluated) of Positive_regulation (frequency) of CD4 in T cells
2) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2749339 Disease Relevance 0.23 Pain Relevance 0

General Comments

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