INT28278

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Context Info
Confidence 0.43
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.75
Pain Relevance 0.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Oxt) extracellular region (Oxt) response to stress (Oxt)
cytoplasm (Oxt)
Anatomy Link Frequency
supraoptic nucleus 2
nucleus 2
Oxt (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 2 99.36 Very High Very High Very High
narcan 6 98.42 Very High Very High Very High
withdrawal 1 96.88 Very High Very High Very High
Intracerebroventricular 1 85.52 High High
gABA 16 84.48 Quite High
Morphine 6 84.20 Quite High
Somatostatin 5 82.32 Quite High
Dopamine 35 5.00 Very Low Very Low Very Low
Locus ceruleus 10 5.00 Very Low Very Low Very Low
midbrain 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Schizophrenia 220 97.38 Very High Very High Very High
Autism 8 89.28 High High
Congenital Anomalies 44 50.00 Quite Low
Suicidal Behaviour 2 31.96 Quite Low
Galactorrhea 4 27.92 Quite Low
Urological Neuroanatomy 4 10.48 Low Low
Disease 26 5.00 Very Low Very Low Very Low
Stress 14 5.00 Very Low Very Low Very Low
Apoptosis 12 5.00 Very Low Very Low Very Low
Attention Deficit Hyperactivity Disorder 10 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Does acute, intense stimulation of oxytocin neurones in the supraoptic nucleus increase their content of oxytocin mRNA?
Positive_regulation (increase) of oxytocin Binding (content) of in supraoptic nucleus associated with narcan
1) Confidence 0.43 Published 1989 Journal Brain Res. Section Title Doc Link 2743158 Disease Relevance 0 Pain Relevance 0.33
In an animal model of schizophrenia, prenatally stressed rats exhibit social withdrawal similar to schizophrenia that is reversible with oxytocin administration.155 Stressed male rats have less oxytocin mRNA in the paraventricular nucleus and increased oxytocin receptor binding in the central amygdala.155 Other studies have also found that the central oxytocinergic system may be responsible for social impairments in schizophrenia.156 Reduced oxytocin receptors downregulate reelin that may contribute to social behaviors of schizophrenia and autism.157 Oral BPA exposure reduces certain maternal behaviors such as licking-grooming and arched back posture related to oxytocin.158 These effects are likely related to BPA's effect on estrogen-inducible central oxytocin receptors.158

Corticotropin-Releasing Hormone.

Positive_regulation (increased) of oxytocin Binding (binding) of in nucleus associated with autism, amygdala, withdrawal and schizophrenia
2) Confidence 0.03 Published 2009 Journal Schizophrenia Bulletin Section Body Doc Link PMC2643957 Disease Relevance 0.75 Pain Relevance 0.43

General Comments

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