INT2828

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Context Info
Confidence 0.68
First Reported 1979
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 26
Total Number 27
Disease Relevance 8.01
Pain Relevance 9.63

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
cerebrospinal fluid 5
brain 2
nociceptor 2
spinal 2
plasma 1
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 16 100.00 Very High Very High Very High
Hyperalgesia 14 100.00 Very High Very High Very High
Thermal hyperalgesia 2 100.00 Very High Very High Very High
hypoalgesia 1 100.00 Very High Very High Very High
agonist 23 99.98 Very High Very High Very High
nociceptor 8 99.90 Very High Very High Very High
Paracetamol 27 99.66 Very High Very High Very High
Arthritis 9 99.66 Very High Very High Very High
analgesia 1 99.40 Very High Very High Very High
Sciatic nerve 4 99.24 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hyperalgesia 17 100.00 Very High Very High Very High
Hypoalagesia 1 100.00 Very High Very High Very High
Nociception 11 99.80 Very High Very High Very High
Arthritis 8 99.66 Very High Very High Very High
Hypersensitivity Vasculitis 10 99.62 Very High Very High Very High
Overactive Bladder 3 99.28 Very High Very High Very High
Cv General 2 Under Development 6 99.08 Very High Very High Very High
INFLAMMATION 38 98.80 Very High Very High Very High
Bacterial Infection 1 98.48 Very High Very High Very High
Fever 9 97.72 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that direct agonist-activation of EP3 receptor depolarizes the membrane by a cationic conductance, leading to excitation of DR neurons, and indicate a physiological implication that EP3 receptor may modulate the serotonergic inhibition of neuronal activities.
Positive_regulation (activation) of EP3 receptor in neurons associated with agonist
1) Confidence 0.68 Published 1996 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 8935703 Disease Relevance 0 Pain Relevance 0.42
Analysis of these data, collectively, supports the hypothesis that prostaglandins regulate trigeminal TRPV(1) nociceptors via activation of the EP2 and EP3 receptors.
Positive_regulation (activation) of EP3 in nociceptors associated with nociceptor
2) Confidence 0.64 Published 2008 Journal J. Dent. Res. Section Abstract Doc Link 18296611 Disease Relevance 0.11 Pain Relevance 0.54
These findings indicate that the LCV injection of PGE2 induces thermal hyperalgesia through EP3 receptors and analgesia through EP1 receptors by its central action in rats.
Positive_regulation (induces) of EP3 in PGE2 associated with thermal hyperalgesia, hypersensitivity vasculitis and analgesia
3) Confidence 0.50 Published 1994 Journal Brain Res. Section Abstract Doc Link 7874513 Disease Relevance 0.76 Pain Relevance 0.60
We found that cell profiles immunoreactive (IR) for four EP receptors, EP1, EP2, EP3, and EP4, are dramatically increased in injured nerve 2 and 4 weeks after PSNL.
Positive_regulation (increased) of EP3 in nerve
4) Confidence 0.48 Published 2003 Journal Exp. Neurol. Section Abstract Doc Link 14552899 Disease Relevance 0.23 Pain Relevance 0.44
CONCLUSIONS: Spinal PGE(2) levels are similarly increased after i.t. levobupivacaine injection of 250 and 100 microg.
Positive_regulation (increased) of PGE in Spinal
5) Confidence 0.47 Published 2009 Journal Br J Anaesth Section Body Doc Link 19252201 Disease Relevance 0 Pain Relevance 0
PGE content in inflamed synovial membrane was increased markedly, and PGE and F content in inflamed and non-inflamed synovial membrane was decreased markedly by aspirin in vivo.
Positive_regulation (increased) of PGE associated with aspirin
6) Confidence 0.40 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 544394 Disease Relevance 0.23 Pain Relevance 0.28
RESULTS: Prolonged spinal PGE(2) increases lasting 50-120 min were observed after levobupivacaine injection.
Positive_regulation (increases) of PGE in spinal
7) Confidence 0.34 Published 2009 Journal Br J Anaesth Section Body Doc Link 19252201 Disease Relevance 0 Pain Relevance 0
This allowed sampling dialysates of cerebrospinal fluid (CSF) for measuring PGE(2) and glutamate levels.
Positive_regulation (measuring) of PGE in cerebrospinal fluid
8) Confidence 0.34 Published 2009 Journal Br J Anaesth Section Body Doc Link 19252201 Disease Relevance 0 Pain Relevance 0
A higher PGE(2) response was observed after a second i.t. injection in the animals receiving 1000 microg lidocaine than those receiving 400 mg lidocaine or either dose of levobupivacaine.


Positive_regulation (response) of PGE
9) Confidence 0.34 Published 2009 Journal Br J Anaesth Section Body Doc Link 19252201 Disease Relevance 0 Pain Relevance 0
These results provide electrophysiological evidence that brain-derived PGE2 induces mechanical hyperalgesia and hypoalgesia through EP3 and EP1 receptors, respectively, in the rat.
Positive_regulation (induces) of EP3 in brain associated with hyperalgesia and hypoalgesia
10) Confidence 0.22 Published 1997 Journal Brain Res. Section Abstract Doc Link 9401748 Disease Relevance 0.88 Pain Relevance 0.51
The present study investigated the febrile response in zymosan-induced arthritis, as well as the increase in PGE(2) concentration in the cerebrospinal fluid (CSF), along with the effects of antipyretic drugs on these responses in rats.
Positive_regulation (increase) of PGE in cerebrospinal fluid associated with cv general 2 under development and arthritis
11) Confidence 0.20 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19244587 Disease Relevance 0.40 Pain Relevance 0.09
Zymosan increased PGE(2) concentration in the CSF but not in the plasma.
Neg (not) Positive_regulation (increased) of PGE in plasma
12) Confidence 0.20 Published 2009 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 19244587 Disease Relevance 0.90 Pain Relevance 0.48
It increases the prostaglandin E(2) (PGE(2)) levels in the preoptic area of the hypothalamus (POA) and the microinjection of PGE(2) into the POA and the neighboring basal forebrain induces hyperalgesia.
Positive_regulation (increases) of PGE in POA associated with hyperalgesia
13) Confidence 0.11 Published 2001 Journal Brain Res. Section Abstract Doc Link 11597589 Disease Relevance 0.51 Pain Relevance 0.27
The fast-type current was attributed to activation of P2X3 subtype and the slow type to the P2X2 subtype.
Positive_regulation (activation) of P2X3 subtype
14) Confidence 0.08 Published 2003 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 14719026 Disease Relevance 0.40 Pain Relevance 0.23
CGRP mRNA expression was increased in the dorsal root ganglion (DRG) at 2 and 4 wk, whereas PGE and iNOS mRNAs were markedly increased at 2 wk.
Positive_regulation (increased) of PGE in dorsal root ganglion
15) Confidence 0.07 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19762759 Disease Relevance 0.06 Pain Relevance 0
We quantitated mRNA levels for enzymes involved in the prostaglandin biosynthetic pathways and found that both COX-2 and PGE synthase (PGEs) mRNA levels were increased in the brain; no changes were found for expression of COX-1 or PGD synthase mRNA.
Positive_regulation (increased) of PGE synthase in brain
16) Confidence 0.06 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12183639 Disease Relevance 0.30 Pain Relevance 0.42
The increment of CGRP, PGE, and iNOS also suggest pain-related signal processing between the IVD and the neural pathway in this animal model.
Positive_regulation (increment) of PGE in neural
17) Confidence 0.05 Published 2009 Journal Anesth. Analg. Section Body Doc Link 19762759 Disease Relevance 0 Pain Relevance 0
In addition, the selective COX-2 inhibitor NS398 (1 microM) was equally as effective as acetaminophen in blocking LPS-induced PGE(2) production.
Positive_regulation (induced) of PGE associated with paracetamol and cox-2 inhibitor
18) Confidence 0.05 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15618346 Disease Relevance 0 Pain Relevance 1.01
Acetaminophen dose-dependently inhibited both basal and LPS-induced PGE(2) production in CECs with IC(50) values of 15.5 and 6.9 microM, respectively.
Positive_regulation (induced) of PGE in CECs associated with paracetamol
19) Confidence 0.05 Published 2005 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 15618346 Disease Relevance 0 Pain Relevance 0.76
PGE(2) levels also increased in the spinal cord and, to a lesser extent, in the brain and remained elevated in both the cerebrospinal fluid and the spinal cord during the late phase.
Positive_regulation (increased) of PGE in cerebrospinal fluid associated with spinal cord
20) Confidence 0.05 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15044444 Disease Relevance 0.57 Pain Relevance 0.56

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