INT282820

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.88
Pain Relevance 0.39

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (NCOR2) small molecule metabolic process (NCOR2) nucleolus (NCOR2)
nucleus (NCOR2) plasma membrane (TACR1) DNA binding (NCOR2)
TACR1 (Homo sapiens)
NCOR2 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 4 100.00 Very High Very High Very High
chemokine 2 100.00 Very High Very High Very High
cytokine 1 100.00 Very High Very High Very High
Neurobehavioral 1 90.24 High High
substance P 2 88.92 High High
Pain management 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Acquired Immune Deficiency Syndrome Or Hiv Infection 12 100.00 Very High Very High Very High
Immunodeficiency 1 95.28 Very High Very High Very High
Infection 3 80.44 Quite High
Mental Disorders 1 60.40 Quite High
Communicable Diseases 1 58.60 Quite High
Hypersensitivity 1 57.68 Quite High
Disease 5 5.00 Very Low Very Low Very Low
Vomiting 2 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The goal of this specific Integrated Preclinical/Clinical Program (IPCP) is to identify an NK-1R antagonist that is: (a) active as an anti-HIV agent through interaction with chemokine/cytokine receptors (Project 1); (b) specific for chemokine and G-protein coupled receptors (Project 2); (c) safe for use in SIV (simian immunodeficiency virus)-infected non-human primates and provides proof of concept related to antiviral, immunomodulatory, and neurobehavioral effects (Project 3); and (d) safe in humans and has positive immunomodulatory effects (Project 4).
NK-1R Binding (interaction) of receptors associated with chemokine, antagonist, acquired immune deficiency syndrome or hiv infection, neurobehavioral, immunodeficiency and cytokine
1) Confidence 0.00 Published 2008 Journal AAPS J Section Body Doc Link PMC2751447 Disease Relevance 0.88 Pain Relevance 0.39

General Comments

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