INT282824

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 2.66
Pain Relevance 0.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (PML) nucleoplasm (PML) endoplasmic reticulum (PML)
intracellular (PML) protein complex assembly (PML) DNA binding (PML)
Anatomy Link Frequency
blood 1
arm 1
PML (Homo sapiens)
Pain Link Frequency Relevance Heat
cva 4 89.20 High High
Multiple sclerosis 5 81.84 Quite High
withdrawal 1 44.32 Quite Low
dexamethasone 7 26.40 Quite Low
Paracetamol 1 6.48 Low Low
Pain 7 5.00 Very Low Very Low Very Low
headache 5 5.00 Very Low Very Low Very Low
antidepressant 2 5.00 Very Low Very Low Very Low
Arthritis 2 5.00 Very Low Very Low Very Low
methotrexate 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Progressive Multifocal Leukoencephalopathy 13 100.00 Very High Very High Very High
Acute Promyelocytic Leukemia 28 98.22 Very High Very High Very High
Opportunistic Infections 1 95.16 Very High Very High Very High
Hemorrhage 9 92.92 High High
Disease 14 90.24 High High
Isochromosomes 4 90.16 High High
Drug-induced Liver Injury 2 89.20 High High
Cancer 8 88.08 High High
Epstein-barr Virus 4 86.72 High High
Injury 11 83.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
APL is characterized by a translocation between chromosomes 15 and 17, which results in the fusion of PML gene on the long arm of chromosome 15 with RAR?
Regulation (fusion) of PML in arm associated with acute promyelocytic leukemia
1) Confidence 0.44 Published 2010 Journal The Korean Journal of Hematology Section Body Doc Link PMC3023048 Disease Relevance 1.13 Pain Relevance 0.04
The TOUCH Prescribing Program is designed to provide a highly effective registry for PML which is based on drug exposure and relies on a highly specialized health care environment.


Regulation (relies) of PML associated with progressive multifocal leukoencephalopathy
2) Confidence 0.14 Published 2008 Journal AAPS J Section Body Doc Link PMC2751449 Disease Relevance 1.05 Pain Relevance 0.04
It is currently unknown which if any of these differences may explain why the subtle effects on PML-NB distribution that we observed upon expression of the HHV-5 CHPK failed to reach statistical significance.
Regulation (effects) of PML
3) Confidence 0.07 Published 2010 Journal PLoS Pathogens Section Body Doc Link PMC2936540 Disease Relevance 0.24 Pain Relevance 0
EBB was involved in all aspects of this study, including generation of the initial draft of the manuscript; RGM performed all blood cultures, PCR, sequencing and molecular data analyses, PML and CWW were responsible for patient evaluation, medical record review and patient follow-up, BCH and JMB were responsible for serological testing.
Spec (analyses) Regulation (responsible) of PML in blood
4) Confidence 0.02 Published 2010 Journal Parasit Vectors Section Body Doc Link PMC2859367 Disease Relevance 0.24 Pain Relevance 0

General Comments

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