INT282840

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Context Info
Confidence 0.06
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mcat)
Anatomy Link Frequency
neurons 1
astrocytes 1
Mcat (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 2 15.56 Low Low
Glutamate 2 14.44 Low Low
cINOD 6 5.00 Very Low Very Low Very Low
Bioavailability 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 84 44.24 Quite Low
Diabetes Mellitus 2 30.64 Quite Low
Starvation 2 28.40 Quite Low
Apoptosis 30 5.00 Very Low Very Low Very Low
Malignant Neoplastic Disease 16 5.00 Very Low Very Low Very Low
Colon Cancer 10 5.00 Very Low Very Low Very Low
INFLAMMATION 6 5.00 Very Low Very Low Very Low
Breast Cancer 4 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Inflammatory Bowel Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These studies show that the high-affinity sodium-coupled MCT SLC5A8 is expressed specifically in neurons in the brain, suggesting that the transporter might play an important role in the neuronal uptake of lactate and ketone bodies and thus in the maintenance of energy status of the neurons.
Positive_regulation (coupled) of MCT in neurons
1) Confidence 0.06 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0 Pain Relevance 0
In contrast, the low-affinity sodium-coupled MCT SLC5A12 is expressed specifically in astrocytes (26).
Positive_regulation (coupled) of MCT in astrocytes
2) Confidence 0.06 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0 Pain Relevance 0

General Comments

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