INT282852

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.77
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc5a8) plasma membrane (Slc5a8) transmembrane transport (Slc5a8)
Slc37a4 (Mus musculus)
Slc5a8 (Mus musculus)
Pain Link Frequency Relevance Heat
cINOD 9 92.72 High High
Bioavailability 9 85.36 High High
Glutamate 3 5.00 Very Low Very Low Very Low
Neurotransmitter 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 9 92.48 High High
Cancer 126 86.80 High High
Apoptosis 45 73.36 Quite High
Inflammatory Bowel Disease 3 18.64 Low Low
Colon Cancer 15 6.08 Low Low
Malignant Neoplastic Disease 24 5.00 Very Low Very Low Very Low
Breast Cancer 6 5.00 Very Low Very Low Very Low
Diabetes Mellitus 3 5.00 Very Low Very Low Very Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Starvation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SLC5A8 is a Na+-coupled, electrogenic, high-affinity transporter for short-chain fatty acids, lactate, pyruvate, nicotinate, and ketone bodies.
transporter Binding (affinity) of SLC5A8
1) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0.22 Pain Relevance 0
Subsequent studies with lactate and pyruvate as substrates showed that SLC5A8 also functions as a Na+-coupled transporter for these monocarboxylates (6,8).
transporter Binding (coupled) of SLC5A8
2) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0 Pain Relevance 0
These studies have shown that benzoate, salicylate, and 5-aminosalicylate are transported via SLC5A8. p-Aminobenzoate is not recognized by the transporter.
transporter Binding (recognized) of SLC5A8
3) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2751467 Disease Relevance 0.55 Pain Relevance 0.21

General Comments

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