INT2829

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Context Info
Confidence 0.43
First Reported 1979
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.63
Pain Relevance 1.29

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Ptger3) signal transducer activity (Ptger3)
Anatomy Link Frequency
PGE 1
uterus 1
Ptger3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 2 99.48 Very High Very High Very High
gABA 7 95.32 Very High Very High Very High
Morphine 4 87.76 High High
Inflammation 9 75.00 Quite High
Analgesic 5 75.00 Quite High
cINOD 3 75.00 Quite High
analgesia 2 71.04 Quite High
GABAergic 1 64.36 Quite High
Central nervous system 1 55.08 Quite High
Disease Link Frequency Relevance Heat
Fever 14 100.00 Very High Very High Very High
INFLAMMATION 7 80.92 Quite High
Nociception 2 59.60 Quite High
Disease 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This hyperthermia was not affected by prior administration of antiserotonergic (pCPA, 5.6-DHT) or anticatecholaminergic (PBZ, 6-OHDA) drugs, as well as by PGE synthetase inhibitor, indomethacin.
Negative_regulation (inhibitor) of PGE synthetase associated with fever
1) Confidence 0.43 Published 1981 Journal Indian J. Physiol. Pharmacol. Section Abstract Doc Link 7298148 Disease Relevance 0.25 Pain Relevance 0.32
RESULTS: The inhibition of PGE(2) and TXB(2) could be described by a sigmoid E(max) model.
Negative_regulation (inhibition) of PGE
2) Confidence 0.37 Published 2010 Journal Eur J Pain Section Body Doc Link 19679500 Disease Relevance 0.08 Pain Relevance 0
PGE content in inflamed synovial membrane was increased markedly, and PGE and F content in inflamed and non-inflamed synovial membrane was decreased markedly by aspirin in vivo.
Negative_regulation (decreased) of PGE associated with aspirin
3) Confidence 0.37 Published 1979 Journal Nippon Yakurigaku Zasshi Section Abstract Doc Link 544394 Disease Relevance 0.22 Pain Relevance 0.28
IC(50) values for PGE(2) inhibition showed a shift from 2840+/-510 to 4000+/-677ng/ml(mean+/-SD), whilst IC(50) values for TXB(2) inhibition increased from 1180+/-323 to 3360+/-453ng/ml in healthy and FCA-inoculated animals, respectively.
Negative_regulation (inhibition) of PGE
4) Confidence 0.27 Published 2010 Journal Eur J Pain Section Body Doc Link 19679500 Disease Relevance 0.07 Pain Relevance 0
An increased dose of dipyrone (50 mg/kg, i.v.) was required to attenuate this IL-1 beta fever; however, the PGE fever remained unaffected by this treatment with dipyrone.
Neg (unaffected) Negative_regulation (unaffected) of PGE in PGE associated with fever
5) Confidence 0.24 Published 1994 Journal Agents Actions Section Abstract Doc Link 7942328 Disease Relevance 1.01 Pain Relevance 0.35
Almost similar results (i.e. inhibition of contractile responses to AA and PGE(2)) were obtained with isolated non-pregnant rat uterus.
Negative_regulation (inhibition) of PGE in uterus
6) Confidence 0.03 Published 2003 Journal Pharmacol. Res. Section Abstract Doc Link 12742000 Disease Relevance 0 Pain Relevance 0.34

General Comments

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