INT282919

Context Info Confidence 0.12 First Reported 2009 Last Reported 2011 Negated 0 Speculated 1 Reported most in Body Documents 1 Total Number 2 Disease Relevance 1.53 Pain Relevance 0.52

cytoplasm (MMP14)

MMP14 (Homo sapiens)

Pain Link Frequency Relevance Heat rheumatoid arthritis 7 98.40 Inflammation 17 97.40 metalloproteinase 46 68.40 chemokine 3 55.76 cytokine 2 55.28 Neuropathic pain 1 53.68 Multiple sclerosis 4 5.00 peptic ulcer disease 4 5.00 Pain 3 5.00 Inflammatory response 2 5.00

Disease Link Frequency Relevance Heat Atherosclerosis 2 98.96 Rheumatoid Arthritis 7 98.40 INFLAMMATION 19 97.40 Infection 29 96.00 Atherosclerotic Plaque 1 71.60 Disease 18 71.48 Sprains And Strains 26 60.40 Frailty 3 59.68 Renal Disease 1 57.92 Neuropathic Pain 1 53.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Johnson et al. have highlighted MMP-14 as a potential target for the stabilization of atherosclerotic lesions [129].

Regulation (target) of MMP-14 associated with atherosclerosis

1) Confidence 0.12 Published 2011 Journal Biochemistry Research International Section Body Doc Link PMC2989751 Disease Relevance 1.17 Pain Relevance 0.52

These data indicate that MMP-14 is partially involved in the MUC1 shedding process in MKN7 cells.

Spec (partially) Regulation (involved) of MMP-14

2) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752161 Disease Relevance 0.36 Pain Relevance 0

General Comments

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