INT282944

Context Info Confidence 0.11 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0 Pain Relevance 0.03

cytosol (POU5F1) nucleoplasm (POU5F1) nucleus (POU5F1) DNA binding (POU5F1) transcription factor binding (POU5F1) cytoplasm (POU5F1)

POU5F1 (Homo sapiens)

Pain Link Frequency Relevance Heat antagonist 3 62.72 nMDA receptor 3 5.00 Glutamate receptor 3 5.00 agonist 3 5.00 imagery 3 5.00 Action potential 2 5.00 tetrodotoxin 1 5.00 Spinal cord 1 5.00 gABA 1 5.00 Glutamate 1 5.00

Disease Link Frequency Relevance Heat Neurodegenerative Disease 4 44.52 Disease 1 34.16 Leukemia 1 5.00 Peripheral Arterial Disease 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

By comparison, addition of the activin/nodal receptor kinase (ALK4/5/7) inhibitor SB431542 results in accelerated loss of OCT4 and NANOG by D4, and gain of both MUSASHI (D4) and SOX1 (D8, Fig. 1B).

Negative_regulation (inhibitor) of Negative_regulation (loss) of OCT4

1) Confidence 0.11 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2752165 Disease Relevance 0 Pain Relevance 0.03

General Comments

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