INT282977

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Context Info
Confidence 0.25
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 2.29
Pain Relevance 0.04

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Becn1) cytoplasmic membrane-bounded vesicle (Becn1) cytoskeleton (Becn1)
cell cycle (Becn1) cell division (Becn1) protein complex (Becn1)
Anatomy Link Frequency
brains 1
groove 1
Becn1 (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 12 86.48 High High
Hippocampus 10 5.00 Very Low Very Low Very Low
Clonidine 7 5.00 Very Low Very Low Very Low
Limbic system 6 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Locus ceruleus 2 5.00 Very Low Very Low Very Low
Neurobehavioral 2 5.00 Very Low Very Low Very Low
Substantia nigra 2 5.00 Very Low Very Low Very Low
Immobilon 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 118 99.74 Very High Very High Very High
Disease 161 99.68 Very High Very High Very High
Stress 19 92.84 High High
Neurodegenerative Disease 32 80.88 Quite High
Death 10 76.44 Quite High
Starvation 20 68.72 Quite High
Targeted Disruption 29 65.12 Quite High
Infection 61 50.00 Quite Low
Lewy Body Disease 12 50.00 Quite Low
Acquired Immune Deficiency Syndrome Or Hiv Infection 1 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, in the brains of patients with AD, levels of the AV protein Beclin-1 are severely down modulated [34].
Regulation (modulated) of AV protein Beclin-1 in brains associated with disease
1) Confidence 0.25 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 1.22 Pain Relevance 0
Consistent with previous studies [34], levels of Beclin-1 in the membrane fractions were reduced in the AD cases compared to non-demented controls and DLB, however no differences in Beclin-1 levels were detected between non-demented controls and DLB cases (Figure 1A, C).
Regulation (differences) of Beclin-1 associated with parkinson's disease and disease
2) Confidence 0.21 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.91 Pain Relevance 0.04
These data collectively demonstrate that the BH2 domain of the hydrophobic groove of vBcl-2 is not essential for suppressing Beclin1-mediated autophagy and its elimination does not affect Beclin1 binding, whereas the elimination of ?
Neg (not) Regulation (affect) of Beclin1 in groove
3) Confidence 0.04 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0 Pain Relevance 0
We did not find that thiol antioxidants or vitamin E had any significant effect on levels of Beclin-1 (Fig. 6D and E).
Regulation (effect) of Beclin-1
4) Confidence 0.01 Published 2010 Journal Human Molecular Genetics Section Body Doc Link PMC2916709 Disease Relevance 0.16 Pain Relevance 0

General Comments

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