INT282982

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Context Info
Confidence 0.28
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 6
Disease Relevance 1.77
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Map1lc3a) cytoskeleton (Map1lc3a) cytoplasm (Map1lc3a)
Anatomy Link Frequency
face 2
neurons 1
vesicles 1
Map1lc3a (Mus musculus)
Pain Link Frequency Relevance Heat
Pyramidal cell 6 66.88 Quite High
Clonidine 7 5.00 Very Low Very Low Very Low
antagonist 7 5.00 Very Low Very Low Very Low
Hippocampus 5 5.00 Very Low Very Low Very Low
carbamazepine 4 5.00 Very Low Very Low Very Low
Substantia nigra 4 5.00 Very Low Very Low Very Low
Limbic system 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Locus ceruleus 1 5.00 Very Low Very Low Very Low
halothane 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Parkinson's Disease 89 99.64 Very High Very High Very High
Viral Infection 13 99.18 Very High Very High Very High
Infection 59 93.44 High High
Disease 122 93.00 High High
Apoptosis 123 92.48 High High
Starvation 22 84.76 Quite High
Cancer 14 75.44 Quite High
Necrosis 1 74.96 Quite High
Targeted Disruption 27 66.56 Quite High
Sprains And Strains 4 61.96 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Compared to the unimpaired neurons in the control cases, in DLB brains, mTor and LC3 immunoreactivity were more abundant in neurons displaying ?
LC3 Binding (immunoreactivity) of in neurons associated with parkinson's disease
1) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2824828 Disease Relevance 0.71 Pain Relevance 0.03
LC3-II is bound to both sides of the membrane, and it remains membrane bound even after fusion with lysosomes, after which LC3-II on the cytosolic face of autophagosomes can be recycled (to LC3-I) by Atg4 [10], while the LC3-II on the inner face of the membrane is degraded.


LC3 Binding (bound) of in face
2) Confidence 0.17 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.05 Pain Relevance 0
LC3-II is bound to both sides of the membrane, and it remains membrane bound even after fusion with lysosomes, after which LC3-II on the cytosolic face of autophagosomes can be recycled (to LC3-I) by Atg4 [10], while the LC3-II on the inner face of the membrane is degraded.


LC3 Binding (bound) of in face
3) Confidence 0.13 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.05 Pain Relevance 0
LC3-II is the most widely used marker to study autophagy, as it is the only known protein that specifically associates with autophagosomes and not with other vesicular structures.
LC3 Neg (not) Binding (associates) of
4) Confidence 0.13 Published 2010 Journal Seminars in Cell & Developmental Biology Section Body Doc Link PMC2938570 Disease Relevance 0.06 Pain Relevance 0
The only known mammalian protein that specifically associates with the autophagosome membrane (as opposed to other vesicles) is MAP1 LC3 (microtubule-associated protein 1 light chain 3), which is post-translationally modified into cytosolic LC3-I, which conjugates with phosphatidylethanolamine upon autophagy induction to form autophagosome-associated LC3-II (13).
LC3 Binding (associates) of in vesicles
5) Confidence 0.12 Published 2010 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2856980 Disease Relevance 0.13 Pain Relevance 0
For autophagy levels during viral infection, NIH3T3 cells were transfected with GFP-LC3, then infected with recombinant ?
LC3 Binding (infected) of associated with viral infection
6) Confidence 0.07 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.78 Pain Relevance 0

General Comments

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