INT28300

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.29
Pain Relevance 1.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (GHR) extracellular space (GHR) extracellular region (GHR)
plasma membrane (GHR) nucleus (GHR) cytoplasm (GHR)
Anatomy Link Frequency
liver 2
plasma 1
follicle 1
IM-9 1
GHR (Homo sapiens)
Pain Link Frequency Relevance Heat
Morphine 6 99.48 Very High Very High Very High
Arthritis 36 98.26 Very High Very High Very High
Clonidine 5 98.02 Very High Very High Very High
transdermal 4 97.82 Very High Very High Very High
Opioid 1 94.36 High High
opioid receptor 3 92.00 High High
narcan 6 75.00 Quite High
Central nervous system 2 69.36 Quite High
agonist 10 64.72 Quite High
antagonist 5 60.24 Quite High
Disease Link Frequency Relevance Heat
Growth Problems 200 99.90 Very High Very High Very High
Cholangiocarcinoma 74 99.76 Very High Very High Very High
Juvenile Chronic Polyarthritis 30 98.26 Very High Very High Very High
Rheumatic Diseases 3 98.00 Very High Very High Very High
Hypertension 13 97.14 Very High Very High Very High
Chronic Renal Failure 42 94.44 High High
Apoptosis 30 89.20 High High
Renal Failure 5 88.60 High High
Cancer 77 88.56 High High
Prostate Cancer 53 85.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In this study, we have investigated the effects of morphine on [125I]hGH binding and GHR gene expression in human lymphoblastoid IM-9 cells.
Gene_expression (expression) of GHR gene in IM-9 associated with morphine
1) Confidence 0.78 Published 1997 Journal Mol. Cell. Endocrinol. Section Abstract Doc Link 9484910 Disease Relevance 0 Pain Relevance 0.70
A PK study of intravenous GH administration found a strong positive correlation between baseline GHBP concentration and MCR at physiological GH concentrations.39 In addition, the reduced GH elimination rate observed in GH-deficient patients in another study was explained by lower levels of GHBP, possibly reflecting a reduced GH receptor density and hence clearance.40
Gene_expression (concentration) of GHBP
2) Confidence 0.45 Published 2007 Journal Clinical Endocrinology Section Body Doc Link PMC2366021 Disease Relevance 0.55 Pain Relevance 0
Interestingly, signaling via growth-hormone receptor (GHR), insulin receptor (INSR) and epidermal growth factor receptor was among the top 10 Networks (score ?
Gene_expression (signaling) of growth-hormone receptor
3) Confidence 0.45 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2957443 Disease Relevance 0.84 Pain Relevance 0
However, most of these have also been found in subjects with normal height, and have been considered to be polymorphisms.59–61 In order to determine whether partial GH-insensitivity was responsible for growth failure in children with ISS, data were analyzed from 773 children who were being treated with GH and were enrolled in a post-marketing surveillance project, the NCGS.62 Patients enrolled in this study had their levels of insuline-like growth factor 1 (IGF-1) and GHBP determined.
Gene_expression (levels) of GHBP associated with growth problems
4) Confidence 0.39 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.46 Pain Relevance 0
GH action is mediated by a GH receptor, which is expressed mainly in the liver and is composed of dimers that change conformation when occupied by a GH ligand (Brown et al 2005).
Gene_expression (expressed) of GH receptor in liver
5) Confidence 0.34 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663454 Disease Relevance 0.22 Pain Relevance 0
Children with ISS had GHBP levels more than 2 SD below the normal control patients, IGF-1 levels lower than controls (108–120 ?
Gene_expression (levels) of GHBP associated with growth problems
6) Confidence 0.34 Published 2010 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2898102 Disease Relevance 0.40 Pain Relevance 0
EGFR expression was examined in 20 surgically resected liver tissues with CC by IHC and 25% (5/20) were EGFR-positive suggesting that this growth hormone receptor is associated with CC [20].
Gene_expression (associated) of growth hormone receptor in liver associated with cholangiocarcinoma
7) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2896958 Disease Relevance 1.33 Pain Relevance 0
Because the phenotype of a rheumatic disease such as SJIA is largely dependent on proteins, the present study was designed to determine whether serum protein expression profiling with SELDI-TOF MS could be used to search for new molecular diagnostic biomarkers and potential therapeutic targets.
Gene_expression (expression) of serum protein associated with rheumatic diseases and arthritis
8) Confidence 0.08 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175022 Disease Relevance 0.34 Pain Relevance 0.05
In eight hypertensive patients treated with transdermal clonidine for one year, there was plasma dilution, as shown by a reduction in serum sodium, hemoglobin, and serum protein levels.
Gene_expression (levels) of serum protein in plasma associated with transdermal, hypertension and clonidine
9) Confidence 0.04 Published 1989 Journal Int J Artif Organs Section Abstract Doc Link 2744881 Disease Relevance 0.10 Pain Relevance 0.34
Before and after 1, 2 and 3 months of therapy, the following circulating steroid and protein hormone levels were evaluated: DHEA, DHEAS, androstenedione, testosterone, estrone, estradiol, 17-hydroxyprogesterone, sex hormone-binding globulin (SHBG), follicle-stimulating hormone (FSH), luteinizing hormone (LH), beta-endorphin, growth hormone (GH) and cortisol, and a Kupperman score was performed.
Gene_expression (evaluated) of protein hormone in follicle
10) Confidence 0.00 Published 1999 Journal Gynecol. Endocrinol. Section Abstract Doc Link 10368794 Disease Relevance 0.06 Pain Relevance 0.41

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