INT283010

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.45
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Bcl2, Becn1) mitochondrion (Bcl2) growth (Bcl2)
cell death (Bcl2) nucleus (Bcl2) cell division (Becn1)
Anatomy Link Frequency
groove 2
Bcl2 (Mus musculus)
Becn1 (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 2 5.00 Very Low Very Low Very Low
halothane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 208 99.38 Very High Very High Very High
Infection 102 78.16 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 2 50.00 Quite Low
Viral Infection 26 20.32 Low Low
Toxicity 2 14.84 Low Low
Sarcoma 2 6.56 Low Low
Epstein-barr Virus 2 5.80 Low Low
Sprains And Strains 8 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Starvation 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Nonetheless, due to the engagement of the hydrophobic surface groove of vBcl-2 by both the pro-autophagic BH3 domain of Beclin1 and the pro-apoptotic BH3 domain [28], mutations of vBcl-2 identified so far that disrupt Beclin1 binding and inhibition of autophagy also abolish its capacity to interact with BH3 peptides and inhibit apoptosis, adding to the complexity of genetically dissecting the in vivo role of vBcl-2-mediated autophagy inhibition and the vBcl-2-mediated antagonism of apoptosis in ?
Regulation (disrupt) of vBcl-2 Binding (binding) of Beclin1 in groove associated with apoptosis
1) Confidence 0.03 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.73 Pain Relevance 0
We show that removing the BH2 domain from vBcl-2 does not affect vBcl-2's capacity to bind and suppress Beclin1, but it significantly dampens its anti-apoptotic activity.
Neg (not) Regulation (affect) of vBcl-2 Binding (bind) of Beclin1 associated with apoptosis
2) Confidence 0.02 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2752191 Disease Relevance 0.72 Pain Relevance 0

General Comments

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