INT283020

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Context Info
Confidence 0.37
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 0.64
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Afp) extracellular space (Afp) extracellular region (Afp)
cytoplasm (Afp)
Anatomy Link Frequency
embryonic stage 2
Afp (Mus musculus)
Pain Link Frequency Relevance Heat
Neurotransmitter 1 24.16 Low Low
corticosteroid 1 22.72 Low Low
alcohol 1 21.20 Low Low
anesthesia 8 5.00 Very Low Very Low Very Low
Bile 5 5.00 Very Low Very Low Very Low
tolerance 2 5.00 Very Low Very Low Very Low
Analgesic 1 5.00 Very Low Very Low Very Low
Paracetamol 1 5.00 Very Low Very Low Very Low
Somatostatin 1 5.00 Very Low Very Low Very Low
substance P 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Feminization 8 97.88 Very High Very High Very High
Malignant Neoplastic Disease 1 87.56 High High
Targeted Disruption 48 84.52 Quite High
Lordosis 52 81.68 Quite High
Liver Cancer 1 76.84 Quite High
Shock 2 69.24 Quite High
Disease 1 66.52 Quite High
Congenital Anomalies 4 38.40 Quite Low
Reprotox - General 3 4 26.12 Quite Low
Hepatocellular Cancer 9 25.52 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Because the binding activity of AFP for E2 depends on conditions [18,25] such as carbohydrate modifications, embryonic stage (15-18 days of gestation) and purification methods, crude serum samples were used for monitoring the in vivo states affecting brain development.
AFP Binding (binding) of in embryonic stage
1) Confidence 0.37 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0 Pain Relevance 0
Because the binding activity of AFP for E2 depends on conditions [18,25] such as carbohydrate modifications, embryonic stage (15-18 days of gestation) and purification methods, crude serum samples were used for monitoring the in vivo states affecting brain development.
AFP Binding (activity) of in embryonic stage
2) Confidence 0.37 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0 Pain Relevance 0
Feminization is known to be induced by blocking estrogen action during embryonic development, which is achieved by an alpha-fetoprotein binding to circulating estradiol in the female fetus [9,32].
alpha-fetoprotein Binding (binding) of associated with feminization
3) Confidence 0.35 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.10 Pain Relevance 0
Estradiol binding was only reported for murine AFP [17-19].
AFP Binding (binding) of
4) Confidence 0.31 Published 2010 Journal BMC Genet Section Body Doc Link PMC2912782 Disease Relevance 0.24 Pain Relevance 0
Notably, these biomarkers were significantly associated with serum AFP levels in clinical cases of HCC [32].
serum AFP Binding (associated) of
5) Confidence 0.02 Published 2009 Journal Proteome Sci Section Body Doc Link PMC2752743 Disease Relevance 0.30 Pain Relevance 0

General Comments

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