INT283044

Context Info Confidence 0.15 First Reported 2009 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 5 Disease Relevance 3.87 Pain Relevance 2.00

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)

Anatomy Link Frequency neurons 2 ganglia 2 Tbpl1 (Mus musculus)

Pain Link Frequency Relevance Heat TRP channel 25 100.00 trigeminal ganglion 66 99.60 dorsal root ganglion 72 99.48 allodynia 79 99.40 Neuronal excitability 3 97.68 Neuropathic pain 49 93.52 Pain 142 79.60 burning pain 4 78.56 Cold hyperalgesia 23 77.20 Peripheral nervous system 6 75.08

Disease Link Frequency Relevance Heat Ganglion Cysts 140 99.60 Neuropathic Pain 182 99.40 Injury 141 98.84 Nociception 56 98.64 Hypersensitivity 43 95.12 Drug Induced Neurotoxicity 9 90.48 Nervous System Injury 66 84.20 Pain 108 79.60 Hyperalgesia 106 76.80 Body Weight 27 56.64

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

To examine whether this phenotype is recapitulated in vivo, we used TaqMan RT-PCR to look at changes in TRP channel gene expression in mouse TG tissues harvested after 3 weeks treatment with platinum drugs [48].

Regulation (changes) of Gene_expression (expression) of TRP associated with trp channel and trigeminal ganglion

1) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.86 Pain Relevance 0.57

These data demonstrate a time dependent transcriptional modulation of the expression pattern of TRP channels on DRG neurons following exposure to cisplatin.

Regulation (modulation) of Gene_expression (expression) of TRP in neurons associated with dorsal root ganglion and trp channel

2) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.43 Pain Relevance 0.27

Our results suggest that cold allodynia does not arise directly from changes in TRP channel expression.

Regulation (changes) of Gene_expression (expression) of TRP associated with trp channel and allodynia

3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.25 Pain Relevance 0.49

However, in agreement with our results in mice, we were unable to detect an upregulation in TRP channel expression in either ganglia following injury.

Neg (unable) Regulation (upregulation) of Gene_expression (expression) of TRP in ganglia associated with trp channel and injury

4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.74 Pain Relevance 0.30

This quantitative approach enabled comparisons of the relative changes in expression of each TRP mRNA in response to platinum drugs at varying time points.

Regulation (changes) of Gene_expression (expression) of TRP mRNA

5) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.59 Pain Relevance 0.38

General Comments

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