INT283044

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Context Info
Confidence 0.15
First Reported 2009
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 5
Disease Relevance 3.87
Pain Relevance 2.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Tbpl1) DNA binding (Tbpl1) cytoplasm (Tbpl1)
Anatomy Link Frequency
neurons 2
ganglia 2
Tbpl1 (Mus musculus)
Pain Link Frequency Relevance Heat
TRP channel 25 100.00 Very High Very High Very High
trigeminal ganglion 66 99.60 Very High Very High Very High
dorsal root ganglion 72 99.48 Very High Very High Very High
allodynia 79 99.40 Very High Very High Very High
Neuronal excitability 3 97.68 Very High Very High Very High
Neuropathic pain 49 93.52 High High
Pain 142 79.60 Quite High
burning pain 4 78.56 Quite High
Cold hyperalgesia 23 77.20 Quite High
Peripheral nervous system 6 75.08 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 140 99.60 Very High Very High Very High
Neuropathic Pain 182 99.40 Very High Very High Very High
Injury 141 98.84 Very High Very High Very High
Nociception 56 98.64 Very High Very High Very High
Hypersensitivity 43 95.12 Very High Very High Very High
Drug Induced Neurotoxicity 9 90.48 High High
Nervous System Injury 66 84.20 Quite High
Pain 108 79.60 Quite High
Hyperalgesia 106 76.80 Quite High
Body Weight 27 56.64 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To examine whether this phenotype is recapitulated in vivo, we used TaqMan RT-PCR to look at changes in TRP channel gene expression in mouse TG tissues harvested after 3 weeks treatment with platinum drugs [48].
Regulation (changes) of Gene_expression (expression) of TRP associated with trp channel and trigeminal ganglion
1) Confidence 0.15 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.86 Pain Relevance 0.57
These data demonstrate a time dependent transcriptional modulation of the expression pattern of TRP channels on DRG neurons following exposure to cisplatin.
Regulation (modulation) of Gene_expression (expression) of TRP in neurons associated with dorsal root ganglion and trp channel
2) Confidence 0.13 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.43 Pain Relevance 0.27
Our results suggest that cold allodynia does not arise directly from changes in TRP channel expression.
Regulation (changes) of Gene_expression (expression) of TRP associated with trp channel and allodynia
3) Confidence 0.09 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.25 Pain Relevance 0.49
However, in agreement with our results in mice, we were unable to detect an upregulation in TRP channel expression in either ganglia following injury.
Neg (unable) Regulation (upregulation) of Gene_expression (expression) of TRP in ganglia associated with trp channel and injury
4) Confidence 0.08 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.74 Pain Relevance 0.30
This quantitative approach enabled comparisons of the relative changes in expression of each TRP mRNA in response to platinum drugs at varying time points.
Regulation (changes) of Gene_expression (expression) of TRP mRNA
5) Confidence 0.06 Published 2010 Journal Mol Pain Section Body Doc Link PMC2848188 Disease Relevance 0.59 Pain Relevance 0.38

General Comments

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