INT283049

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 1.33
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Car2) transport (Trpa1) extracellular space (Car2)
lyase activity (Car2) transmembrane transport (Trpa1) cytoplasm (Car2)
Car2 (Mus musculus)
Trpa1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 2 100.00 Very High Very High Very High
agonist 14 99.68 Very High Very High Very High
Eae 28 99.04 Very High Very High Very High
chronic construction injury 58 90.32 High High
Neuropathic pain 40 81.12 Quite High
qutenza 2 58.88 Quite High
allodynia 52 50.00 Quite Low
TRP channel 10 31.88 Quite Low
Pain 28 5.00 Very Low Very Low Very Low
imagery 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 8 100.00 Very High Very High Very High
Inflammatory Pain 8 99.04 Very High Very High Very High
Injury 132 90.32 High High
Neuropathic Pain 98 88.84 High High
Nervous System Injury 42 72.00 Quite High
Hypersensitivity 16 38.88 Quite Low
Neuroma 2 34.08 Quite Low
Nociception 32 5.00 Very Low Very Low Very Low
Pain 30 5.00 Very Low Very Low Very Low
Hyperalgesia 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
An increased level of Ca2+ via activation of Ca2+ signaling pathways by inflammatory mediators would serve to increase the sensitivity of TRPA1 to its agonists [19].
Ca2 Positive_regulation (increase) of TRPA1 associated with inflammatory mediators and agonist
1) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 1.19 Pain Relevance 0.63
We recently reported that TRPA1 is activated by intracellular Ca2+ and that cold sensitivity occurs indirectly through an increased Ca2+ concentration in HEK293 cells [19].
Ca2 Positive_regulation (activated) of TRPA1
2) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753652 Disease Relevance 0.14 Pain Relevance 0.04

General Comments

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