INT283055

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Context Info
Confidence 0.69
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 2.06
Pain Relevance 0.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ddah1) cytoplasm (Ddah1)
Anatomy Link Frequency
plasma 2
arterioles 2
Ddah1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 9 83.72 Quite High
isoflurane 9 5.00 Very Low Very Low Very Low
Buprenorphine 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 105 99.98 Very High Very High Very High
Stroke 21 98.72 Very High Very High Very High
Coronary Artery Disease 3 83.72 Quite High
Cv Unclassified Under Development 6 80.68 Quite High
Middle Cerebral Artery Infarction 6 69.36 Quite High
Cv General 4 Under Development 3 57.60 Quite High
Pressure And Volume Under Development 6 5.00 Very Low Very Low Very Low
Death 6 5.00 Very Low Very Low Very Low
Peripheral Arterial Disease 6 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent evidence suggests that DDAH-1 overexpression protects from endothelial dysfunction in cerebral arterioles [9].
Positive_regulation (overexpression) of Gene_expression (overexpression) of DDAH-1 in arterioles
1) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753663 Disease Relevance 0.84 Pain Relevance 0.08
In summary, our findings suggest that hDDAH-1 overexpression and concurrent reduction in plasma ADMA concentrations do not change the outcome of stroke.
Positive_regulation (overexpression) of Gene_expression (overexpression) of hDDAH-1 in plasma associated with stroke
2) Confidence 0.60 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2753663 Disease Relevance 0.48 Pain Relevance 0.05
This lack of protection is due to high basal cerebral DDAH activity, which is not further increasable by transgenic overexpression of DDAH.



Positive_regulation (overexpression) of Gene_expression (overexpression) of DDAH associated with targeted disruption
3) Confidence 0.46 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2753663 Disease Relevance 0.74 Pain Relevance 0

General Comments

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