INT28308

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Context Info
Confidence 0.73
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.77
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasmic membrane-bounded vesicle (SLC17A5) plasma membrane (SLC17A5) transmembrane transport (SLC17A5)
Anatomy Link Frequency
plasma 2
upper 1
kidney 1
SLC17A5 (Homo sapiens)
Pain Link Frequency Relevance Heat
headache 7 95.32 Very High Very High Very High
Angina 1 89.36 High High
abdominal pain 4 85.52 High High
alcohol 2 84.80 Quite High
cINOD 2 75.00 Quite High
anesthesia 2 74.12 Quite High
tolerance 8 73.92 Quite High
withdrawal 4 73.44 Quite High
isoflurane 1 49.72 Quite Low
depression 5 43.20 Quite Low
Disease Link Frequency Relevance Heat
Congenital Anomalies 3 99.48 Very High Very High Very High
Pressure And Volume Under Development 40 98.36 Very High Very High Very High
Splenomegaly 3 98.12 Very High Very High Very High
Coronary Artery Disease 1 96.88 Very High Very High Very High
Diarrhoea 21 96.08 Very High Very High Very High
Headache 6 95.32 Very High Very High Very High
Vomiting 28 95.12 Very High Very High Very High
Disorders Of Creatine Metabolism 1 94.60 High High
Asthma 1 94.40 High High
Viremia 1 93.92 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There was a significant decrease in the release of LDH and AST in Group III when compared with Group II (p less than 0.02 and p less than 0.01) respectively.
Localization (release) of AST
1) Confidence 0.73 Published 1989 Journal J Cardiovasc Surg (Torino) Section Abstract Doc Link 2745513 Disease Relevance 0.36 Pain Relevance 0.09
stimulating hormone (TSH), alkaline phosphatase, aspartate aminotransferase (AST), alanine aminotranferase (ALT) and urinary excretion of sodium in 24 h.


Localization (excretion) of AST
2) Confidence 0.73 Published 2010 Journal Clinics (Sao Paulo) Section Body Doc Link PMC2974815 Disease Relevance 0.53 Pain Relevance 0.06
In detail the electrolytes sodium, potassium, total calcium, chloride and inorganic phosphorus; total protein in plasma and the proteins ferritin and transferrin; the metabolites creatinine, urea, uric acid, cholesterol, triglycerides and glucose; and the enzymes creatine kinase, alanine-aminotransferase (ALT), aspartate-aminotransferase (AST), alkaline phosphatase, ?
Localization (aspartate-aminotransferase) of AST in plasma
3) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2699037 Disease Relevance 0.13 Pain Relevance 0.07
Plasma creatinine, creatine kinase, bilirubin and liver enzymes (AST, ALT and alkaline phosphatase) were measured at baseline and 24 hours after infusion.


Localization (creatine kinase) of AST in Plasma
4) Confidence 0.73 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2405947 Disease Relevance 0 Pain Relevance 0
Asparate 2-oxoglutarate aminotransferase (AST), alanine 2-oxoglutarate aminotransferase (ALT), BUN, free cholesterol, triglyceride, non-esterified fatty acid, and LDL-cholesterol were measured with a Shimadzu CL8000 Clinical Chemistry Analyzer (Shimadzu, Ltd., Tokyo, Japan).


Localization (aminotransferase) of AST
5) Confidence 0.73 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266052 Disease Relevance 0.38 Pain Relevance 0.12
In one study with PEG 3350, biochemical follow-up was performed for 12 months, and mild elevation of AST was noted in some children12).
Localization (elevation) of AST
6) Confidence 0.44 Published 2010 Journal Korean Journal of Pediatrics Section Body Doc Link PMC3004485 Disease Relevance 0.90 Pain Relevance 0
Our results indicate that NAG-1 is a potential molecular target of AST in its antitumorigenic and proapoptotic actions, which would have additive effects when used along with PI3K-Akt inhibitors.
Localization (target) of AST
7) Confidence 0.27 Published 2009 Journal Int. J. Cancer Section Abstract Doc Link 19384947 Disease Relevance 0.31 Pain Relevance 0.13
2.0 mg/dL, aspartate aminotransferase (AST)/alanine aminotransferase (ALT) < 3 × upper limit of normal), and kidney (serum creatinine (Crt) ?
Localization (aspartate aminotransferase) of AST in kidney
8) Confidence 0.08 Published 2010 Journal BMC Complement Altern Med Section Body Doc Link PMC3014873 Disease Relevance 0.41 Pain Relevance 0
Diffuse lymphoadenopathy, splenomegaly and ascites were observed associated with biochemical abnormalities of the liver parameters: aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were 1.5 times upper normal range, alkaline phosphatase (AP) twice and gamma-glutamyltransferase (?
Localization (aspartate aminotransferase) of AST in upper associated with pressure and volume under development, splenomegaly and congenital anomalies
9) Confidence 0.07 Published 2010 Journal BMC Gastroenterol Section Body Doc Link PMC2836274 Disease Relevance 2.72 Pain Relevance 0.13
Elevation of AST and ALT was seen in 8% and 10% patients, respectively.
Localization (Elevation) of AST
10) Confidence 0.01 Published 2007 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2376078 Disease Relevance 1.04 Pain Relevance 0.10

General Comments

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