INT283102

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Context Info
Confidence 0.49
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.31
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dag1) extracellular space (Dag1) extracellular region (Dag1)
plasma membrane (Dag1) cytoskeleton (Dag1) nucleus (Dag1)
Anatomy Link Frequency
blood 1
glial cells 1
lateral 1
Dag1 (Mus musculus)
Pain Link Frequency Relevance Heat
ischemia 6 93.44 High High
potassium channel 18 80.40 Quite High
Neurotransmitter 6 48.84 Quite Low
Glutamate 3 36.24 Quite Low
gABA 3 35.12 Quite Low
Inflammation 9 16.08 Low Low
Inflammatory mediators 15 9.20 Low Low
adenocard 15 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retina Disease 75 98.50 Very High Very High Very High
Cv Unclassified Under Development 6 93.44 High High
Death 3 91.48 High High
Pressure And Volume Under Development 60 80.52 Quite High
Gliosis 21 72.72 Quite High
Injury 9 71.40 Quite High
Diabetic Retinopathy 12 61.12 Quite High
Retinal Vein Occlusion 3 59.36 Quite High
Disease 6 42.76 Quite Low
INFLAMMATION 24 16.08 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genetic inactivation of Dp71 (in Dp71-null mice) alters Kir4.1 and AQP4 distribution in Müller glial cells and this mislocation increases the vulnerability of retinal nerve cells to transient ischemia which is associated with neuronal cells death [14], [15].
Positive_regulation (inactivation) of Dp71 in glial cells associated with ischemia and death
1) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.49 Pain Relevance 0.14
Most likely, the function of Dp71 is to stabilize the Kir4.1 and AQP4 channel molecules in specific membrane domains by limiting their lateral diffusion.
Positive_regulation (stabilize) of Dp71 in lateral
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.20 Pain Relevance 0.07
Similar functional deficits were observed in Müller cells from Dp71-null mice even without experimental retinal detachment; moreover, the permeability of the blood-retinal barrier was dramatically increased already in untreated Dp71-null mice as compared to the controls.
Positive_regulation (increased) of Dp71-null in blood associated with retina disease
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.62 Pain Relevance 0

General Comments

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