INT283105

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Context Info
Confidence 0.67
First Reported 2009
Last Reported 2009
Negated 2
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.19
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dag1) extracellular space (Dag1) extracellular region (Dag1)
plasma membrane (Dag1) cytoskeleton (Dag1) nucleus (Dag1)
Dag1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 18 97.40 Very High Very High Very High
Inflammatory mediators 15 93.40 High High
Inflammation 9 30.48 Quite Low
adenocard 15 5.00 Very Low Very Low Very Low
ischemia 6 5.00 Very Low Very Low Very Low
Neurotransmitter 6 5.00 Very Low Very Low Very Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
gABA 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Gliosis 21 99.08 Very High Very High Very High
Retina Disease 75 97.36 Very High Very High Very High
INFLAMMATION 24 93.00 High High
Pressure And Volume Under Development 60 90.20 High High
Stress 9 89.28 High High
Disease 6 60.40 Quite High
Sprains And Strains 15 34.88 Quite Low
Diabetic Retinopathy 12 5.00 Very Low Very Low Very Low
Injury 9 5.00 Very Low Very Low Very Low
Muscular Dystrophy 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Our present results confirm that functional expression of Dp71 is necessary for the highly asymmetric expression of the inwardly rectifying potassium channel Kir4.1 in Müller cells, and suggest that Dp71 downregulation is one step upstream of the Kir4.1 and AQP4 channel alterations in the signaling cascade of reactive gliosis.
Positive_regulation (necessary) of Gene_expression (expression) of Dp71 associated with potassium channel and gliosis
1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.35 Pain Relevance 0.05
Thus suggesting that Dp71 depletion did not induce reactive Müller cells gliosis.


Neg (not) Positive_regulation (induce) of Gene_expression (depletion) of Dp71 associated with gliosis
2) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.51 Pain Relevance 0.04
In the absence of Dp71, the retinal vascular permeability was increased as compared to the controls.
Positive_regulation (increased) of Neg (absence) Gene_expression (absence) of Dp71
3) Confidence 0.45 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.33 Pain Relevance 0.08

General Comments

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