INT283110

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Context Info
Confidence 0.73
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.14
Pain Relevance 0.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dag1) extracellular space (Dag1) extracellular region (Dag1)
plasma membrane (Dag1) cytoskeleton (Dag1) nucleus (Dag1)
Anatomy Link Frequency
blood vessels 1
astrocytes 1
synapse 1
Dag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammatory mediators 15 97.08 Very High Very High Very High
potassium channel 21 94.28 High High
adenocard 15 82.56 Quite High
addiction 3 54.60 Quite High
Central nervous system 8 37.08 Quite Low
Neurotransmitter 30 27.24 Quite Low
Inflammation 14 5.00 Very Low Very Low Very Low
Hippocampus 13 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
ischemia 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alzheimer's Dementia 6 99.66 Very High Very High Very High
Pressure And Volume Under Development 60 99.12 Very High Very High Very High
INFLAMMATION 29 97.08 Very High Very High Very High
Cerebral Amyloid Angiopathy 5 89.40 High High
Targeted Disruption 26 88.24 High High
Muscular Dystrophy 52 83.92 Quite High
Stress 14 83.44 Quite High
Disease 80 82.08 Quite High
Congenital Anomalies 14 79.20 Quite High
Night Blindness 1 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Second, Dp71 immunoreactivity is localized in Müller cell endfeet and processes surrounding retinal blood vessels [14] (Fig.
Localization (localized) of Dp71 in blood vessels
1) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.48 Pain Relevance 0.22
These data suggest that deletion of Dp71 modifies the osmotic swelling characteristics of Müller cells, and that inflammatory mediators are involved in this alteration.


Localization (deletion) of Dp71 associated with pressure and volume under development and inflammatory mediators
2) Confidence 0.73 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.72 Pain Relevance 0.28
These alterations are associated with a strong decrease of Dp71, a cytoskeleton protein responsible for the localization and the clustering of Kir4.1 and AQP4.
Localization (localization) of Dp71
3) Confidence 0.73 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.32 Pain Relevance 0.09
At the ribbon synapse, Dp260, Dp140, and Dp71, as well as ?
Localization (well) of Dp71 in synapse
4) Confidence 0.47 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.37 Pain Relevance 0
A potential explanation for the loss of AQP4 and Kir4.1 channels is that they share a common anchoring protein that is affected by vascular amyloid deposition: the Dp71 dystrophin protein, localized on perivascular astrocytes [40].
Localization (localized) of Dp71 in astrocytes associated with alzheimer's dementia
5) Confidence 0.24 Published 2010 Journal Current Neuropharmacology Section Body Doc Link PMC2923365 Disease Relevance 1.24 Pain Relevance 0.03

General Comments

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