INT283112

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Context Info
Confidence 0.03
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 7
Disease Relevance 2.48
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Kcnj14)
Anatomy Link Frequency
blood vessels 1
retina 1
Kcnj14 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 42 100.00 Very High Very High Very High
Inflammation 21 97.20 Very High Very High Very High
Inflammatory mediators 35 87.52 High High
Neurotransmitter 14 80.52 Quite High
ischemia 14 66.80 Quite High
Glutamate 7 16.16 Low Low
gABA 7 15.04 Low Low
adenocard 35 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Retina Disease 175 99.34 Very High Very High Very High
INFLAMMATION 56 97.20 Very High Very High Very High
Gliosis 49 95.36 Very High Very High Very High
Pressure And Volume Under Development 140 88.52 High High
Cv Unclassified Under Development 14 66.80 Quite High
Death 7 62.88 Quite High
Sprains And Strains 35 50.32 Quite High
Injury 21 45.20 Quite Low
Diabetic Retinopathy 28 41.04 Quite Low
Retinal Vein Occlusion 7 39.28 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Müller cells express the inwardly rectifying K+ channel Kir4.1 and it is well-known from other animal models that Kir-mediated currents may be markedly decreased under pathological conditions [16]–[18], [31].
Gene_expression (express) of Kir4 associated with potassium channel
1) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.55 Pain Relevance 0.05
In the normal retina, the Dp71 protein shows the same expression pattern as Kir4.1 and AQP4; it has been shown to be involved in the targeting of these channels to specific membrane microdomains via a macromolecular protein complex composed by Dp71 and dystrophin-associated proteins (DAPs) [14], [15].
Gene_expression (expression) of Kir4 in retina
2) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.13 Pain Relevance 0.14
In healthy retina, Kir4.1 and AQP4 proteins are strongly expressed by Müller cells where these proteins are particularly enriched in the vitread endfeet and in cell processes abutting the intraretinal blood vessels [10], [11].
Gene_expression (expressed) of Kir4 in blood vessels
3) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0 Pain Relevance 0.14
In addition to failures in Kir4.1 and AQP4 expression and/or membrane insertion, Dp71 deficiency may also induce a chronic inflammation.
Gene_expression (expression) of Kir4 associated with inflammation
4) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.83 Pain Relevance 0.16
Thus, retinal detachment induced a loss of the polarized expression of Kir4.1 but this mislocalization of Kir4.1 was not associated to a decrease of its expression level.
Gene_expression (expression) of Kir4 associated with retina disease
5) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.38 Pain Relevance 0
Our present results confirm that functional expression of Dp71 is necessary for the highly asymmetric expression of the inwardly rectifying potassium channel Kir4.1 in Müller cells, and suggest that Dp71 downregulation is one step upstream of the Kir4.1 and AQP4 channel alterations in the signaling cascade of reactive gliosis.
Gene_expression (expression) of Kir4 associated with potassium channel and gliosis
6) Confidence 0.03 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.37 Pain Relevance 0.05
Earlier it had been shown that utrophin, a cytoskeleton protein, shares the common expression pattern of Dp71, Kir4.1, and AQP4.
Gene_expression (expression) of Kir4
7) Confidence 0.02 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.22 Pain Relevance 0

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