INT283119

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Context Info
Confidence 0.44
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.98
Pain Relevance 0.65

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dag1) extracellular space (Dag1) extracellular region (Dag1)
plasma membrane (Dag1) cytoskeleton (Dag1) nucleus (Dag1)
Anatomy Link Frequency
retinas 1
Dag1 (Mus musculus)
Pain Link Frequency Relevance Heat
potassium channel 18 94.28 High High
Inflammatory mediators 15 93.44 High High
Peripheral nervous system 2 80.20 Quite High
Neurotransmitter 28 76.88 Quite High
gABA 3 75.72 Quite High
Glutamate 6 75.36 Quite High
amygdala 5 72.44 Quite High
adenocard 15 71.56 Quite High
Hippocampus 12 69.96 Quite High
Limbic system 1 68.04 Quite High
Disease Link Frequency Relevance Heat
Muscular Dystrophy 52 97.44 Very High Very High Very High
INFLAMMATION 24 93.04 High High
Pressure And Volume Under Development 60 90.84 High High
Neurological Disease 2 88.52 High High
Diabetic Retinopathy 12 86.40 High High
Disease 11 85.24 High High
Stress 10 81.76 Quite High
Retina Disease 75 79.76 Quite High
Injury 9 75.12 Quite High
Retinal Vein Occlusion 3 64.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were two previous observations which prompted us to study the effect of Dp71 depletion on BRB integrity.
Regulation (effect) of Dp71
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.64 Pain Relevance 0.25
These alterations are associated with a strong decrease of Dp71, a cytoskeleton protein responsible for the localization and the clustering of Kir4.1 and AQP4.
Regulation (responsible) of Dp71
2) Confidence 0.44 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2754330 Disease Relevance 0.32 Pain Relevance 0.08
Previous work on mice had shown that the deletion of Dp71 and the concomitant impairments in DAPs localization cause functio-morphological alterations of Müller glial cells, particularly in the endfoot region where Dp71 and DAPs are concentrated in wildtype retinas [15].
Regulation (concentrated) of Dp71 in retinas
3) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.75 Pain Relevance 0.14
Furthermore, most DMD patients, who exhibit neurological complications, have a genetic deficiency or duplication distal to exon 44 which most likely alters expression of Dp140, Dp116, and/or Dp71 [116].
Regulation (alters) of Dp71 associated with muscular dystrophy
4) Confidence 0.28 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.28 Pain Relevance 0.18

General Comments

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