INT28312

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Context Info
Confidence 0.72
First Reported 1983
Last Reported 2011
Negated 1
Speculated 0
Reported most in Body
Documents 85
Total Number 85
Disease Relevance 37.69
Pain Relevance 9.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (ABCA1) small molecule metabolic process (ABCA1) Golgi apparatus (ABCA1)
ATPase activity (ABCA1) plasma membrane (ABCA1) intracellular (ABCA1)
Anatomy Link Frequency
macrophages 9
eyes 3
plasma 2
brain 2
blood 2
ABCA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
COX-2 inhibitor 247 100.00 Very High Very High Very High
metalloproteinase 115 100.00 Very High Very High Very High
Inflammation 500 99.92 Very High Very High Very High
rheumatoid arthritis 269 99.84 Very High Very High Very High
Adalimumab 5 99.62 Very High Very High Very High
Opioid 2 99.40 Very High Very High Very High
agonist 122 98.40 Very High Very High Very High
cytokine 181 97.80 Very High Very High Very High
Osteoarthritis 6 97.76 Very High Very High Very High
Chronic pancreatitis 4 97.76 Very High Very High Very High
Disease Link Frequency Relevance Heat
Death 140 100.00 Very High Very High Very High
Congenital Anomalies 33 100.00 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 689 99.96 Very High Very High Very High
Adhesions 81 99.96 Very High Very High Very High
INFLAMMATION 583 99.92 Very High Very High Very High
Rheumatoid Arthritis 474 99.84 Very High Very High Very High
Malignant Neoplastic Disease 146 99.84 Very High Very High Very High
Breast Cancer 73 99.84 Very High Very High Very High
Carcinoma 34 99.52 Very High Very High Very High
Cancer 809 99.48 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and immune complex-C1q complexes, diminish expression of both cholesterol 27-hydroxylase, an anti-atherogenic enzyme, and ATP-binding cassette transporter A1 (ABCA1), a protein that controls a cellular pathway for secretion of cholesterol for transport to the liver, in cells relevant to atherogenesis [10,11].
Gene_expression (expression) of ABCA1 in liver associated with atherosclerosis
1) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.50 Pain Relevance 0.23
We therefore examined the effect of non-selective and selective COX-1 inhibitors on 27-hydroxylase and ABCA1 expression.


Gene_expression (expression) of ABCA1
2) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
Non-selective COX inhibition reduces 27-hydroxylase and ABCA1 expression
Gene_expression (expression) of ABCA1
3) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.03
The non-selective COX inhibitor indomethacin also produced a significant reduction in cholesterol 27-hydroxylase and ABCA1 mRNA expression (50 ?
Gene_expression (expression) of ABCA1 mRNA
4) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.06
We showed that in cultured THP-1 human monocytes/macrophages, inhibition of COX-1, COX-2, or both reduced expression of 27-hydroxylase and ABCA1 message (real-time reverse transcription-polymerase chain reaction) and protein (immunoblot).
Gene_expression (expression) of ABCA1 in macrophages
5) Confidence 0.72 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.55 Pain Relevance 0.37
Moreover, this release is not linked to the transcriptional regulation of the ABCA1 gene, because apoA-I induced efflux does not lead to an increase in ABCA1 gene expression (figure 1).
Gene_expression (expression) of ABCA1 gene
6) Confidence 0.69 Published 2010 Journal Lipids Health Dis Section Body Doc Link PMC2917427 Disease Relevance 0.35 Pain Relevance 0
CONCLUSIONS: In eyes that had had HSV keratitis, corneal sensitivity to mechanical forces and heat was significantly impaired, suggesting that axonal damage and/or altered expression of membrane ion channels involved in transduction and membrane excitability affects primarily the mechano- and polymodal nociceptor terminals.
Gene_expression (expression) of membrane in eyes
7) Confidence 0.66 Published 2010 Journal Invest. Ophthalmol. Vis. Sci. Section Body Doc Link 20375335 Disease Relevance 0 Pain Relevance 0
and immune complex-C1q complexes, diminish expression of both cholesterol 27-hydroxylase, an anti-atherogenic enzyme, and ATP-binding cassette transporter A1 (ABCA1), a protein that controls a cellular pathway for secretion of cholesterol for transport to the liver, in cells relevant to atherogenesis [10,11].
Gene_expression (expression) of transporter A1 in liver associated with atherosclerosis
8) Confidence 0.63 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.50 Pain Relevance 0.23
Effects of the specific COX-2 inhibitor NS398 on 27-hydroxylase and ABCA1 level in THP-1 monocytes were reversed by PGE1, PGE2, and PGD2 prostaglandin products of COX-2 (Figure 5).


Gene_expression (products) of ABCA1 in monocytes associated with cox-2 inhibitor
9) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.14
However, TXA2 failed to reverse the effect of NS398 on either 27-hydroxylase or ABCA1 message.
Gene_expression (message) of ABCA1
10) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.16
Effects of the specific COX-2 inhibitor NS398 on 27-hydroxylase and ABCA1 level in THP-1 monocytes were reversed by PGE1, PGE2, and PGD2 prostaglandin products of COX-2 (Figure 5).


Gene_expression (Effects) of ABCA1 in THP-1 associated with cox-2 inhibitor
11) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.14
Reversal of NS398-induced downregulation of 27-hydroxylase and ABCA1 message by PGE2 and PGD2 was also observed in THP-1 macrophages (Figure 6).
Gene_expression (message) of ABCA1 in macrophages
12) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0.16
Similar to 27-hydroxylase, ABCA1 message was reduced after NS398 exposure to approximately 70% of control (50 ?
Gene_expression (message) of ABCA1
13) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
NS398-induced reductions in 27-hydroxylase and ABCA1 message were observed as early as 3 hours and maintained through 72 hours (data not shown).
Gene_expression (message) of ABCA1
14) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
Analysis of 27-hydroxylase and ABCA1 message by QRT-PCR
Gene_expression (message) of ABCA1
15) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0.08 Pain Relevance 0
For ABCA1 detection, macrophage cell lysates were electrophoresed for 1.5 hours at 100 V (10% polyacrylamide gel) and then transferred to a nitrocellulose membrane.
Gene_expression (detection) of ABCA1 in macrophage
16) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC1860062 Disease Relevance 0 Pain Relevance 0
The reverse cholesterol transport proteins cholesterol 27-hydroxylase and ATP-binding cassette transporter A1 (ABCA1) export cholesterol from macrophages.
Gene_expression (export) of ABCA1 in macrophages
17) Confidence 0.62 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.63 Pain Relevance 0.42
Sensitivities of CERP, DLDA and SC are higher (>50%) than the rest (<50%).
Gene_expression (Sensitivities) of CERP
18) Confidence 0.60 Published 2006 Journal Genome Biol Section Body Doc Link PMC1794434 Disease Relevance 0.20 Pain Relevance 0
expression of the lipid transporter ABCA1 (ATP-binding cassette, subfamily A,
Gene_expression (expression) of ABCA1
19) Confidence 0.58 Published 2008 Journal PPAR Research Section Body Doc Link PMC2430035 Disease Relevance 0.66 Pain Relevance 0.13
Reversal of inhibitory effects on 27-hydroxylase and ABCA1 expression by PGD2 and PGE2 suggests involvement of their respective signaling pathways.
Gene_expression (expression) of ABCA1
20) Confidence 0.56 Published 2007 Journal Arthritis Res Ther Section Abstract Doc Link PMC1860062 Disease Relevance 0.05 Pain Relevance 0.03

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