INT283120

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Context Info
Confidence 0.52
First Reported 2009
Last Reported 2009
Negated 0
Speculated 1
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.32
Pain Relevance 0.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Dag1) extracellular space (Dag1) extracellular region (Dag1)
plasma membrane (Dag1) cytoskeleton (Dag1) nucleus (Dag1)
Anatomy Link Frequency
glial cells 2
Dag1 (Mus musculus)
Pain Link Frequency Relevance Heat
Peripheral nervous system 2 80.20 Quite High
potassium channel 24 78.48 Quite High
amygdala 5 72.44 Quite High
Hippocampus 12 69.96 Quite High
Limbic system 1 68.04 Quite High
cerebral cortex 1 67.28 Quite High
Neurotransmitter 30 63.60 Quite High
ischemia 9 59.44 Quite High
Inflammatory mediators 20 17.80 Low Low
Pyramidal cell 4 16.60 Low Low
Disease Link Frequency Relevance Heat
Retina Disease 100 99.98 Very High Very High Very High
Gliosis 29 99.98 Very High Very High Very High
Muscular Dystrophy 54 97.44 Very High Very High Very High
Neurological Disease 2 88.52 High High
Cv Unclassified Under Development 9 59.44 Quite High
Death 4 55.52 Quite High
Obsessive-compulsive Disorder 2 47.48 Quite Low
Anxiety Disorder 2 46.12 Quite Low
Dystonia 2 44.16 Quite Low
Disease 13 43.12 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together these data show that experimental retinal detachment-induced gliosis affects both gene and protein expression of Dp71 in Müller glial cells.
Regulation (affects) of Gene_expression (expression) of Dp71 in glial cells associated with gliosis and retina disease
1) Confidence 0.52 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.34 Pain Relevance 0
The clustering and precise membrane localization of Kir4.1 and AQP4 are dependent on the dystrophin gene product, Dp71 [13]–[15].
Regulation (dependent) of Gene_expression (product) of Dp71
2) Confidence 0.38 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.11 Pain Relevance 0.14
Furthermore, most DMD patients, who exhibit neurological complications, have a genetic deficiency or duplication distal to exon 44 which most likely alters expression of Dp140, Dp116, and/or Dp71 [116].
Regulation (alters) of Gene_expression (expression) of Dp71 associated with muscular dystrophy
3) Confidence 0.28 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.28 Pain Relevance 0.18
This may indicate that generally, the mislocation of Kir4.1 channels in reactive Müller cells results from an alteration in Dp71 expression.
Regulation (alteration) of Gene_expression (expression) of Dp71
4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.15 Pain Relevance 0.06
To determine whether retinal detachment altered the protein and mRNA expression of Dp71 in C57BL/6 mice, we performed Western blot and real-time PCR analysis at 24 hours and 7 days after surgery.
Spec (whether) Regulation (altered) of Gene_expression (expression) of Dp71 associated with retina disease
5) Confidence 0.23 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2754330 Disease Relevance 0.44 Pain Relevance 0

General Comments

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